Secondary Sulfonamides as Effective Lactoperoxidase Inhibitors
Yazarlar (9)
Zeynep Köksal İstanbul Medeniyet Üniversitesi, Türkiye
Ramazan Kalın Erzurum Teknik Üniversitesi, Türkiye
Dr. Öğr. Üyesi Yasemin Camadan Artvin Çoruh Üniversitesi, Türkiye
Dr. Öğr. Üyesi Hande USANMAZ Sinop Üniversitesi, Türkiye
Züleyha Almaz Muş Alparslan Üniversitesi, Türkiye
İlhami Gülçin Atatürk Üniversitesi, Türkiye
Gökçen Taner
Ahmet Ceyhan Gören
Prof. Dr. Hasan Özdemir Atatürk Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | MOLECULES (Q2) | ||
| Dergi ISSN | 1420-3049 Dergi Bilgileri (2017) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2017 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 24-05-2017 |
| Cilt / Sayı / Sayfa | 22 / 6 / 793–0 | DOI | 10.3390/molecules22060793 |
| Makale Linki | http://www.mdpi.com/1420-3049/22/6/793 | ||
| UAK Araştırma Alanları |
Biyokimya
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| Özet |
| Secondary sulfonamides (4a–8h) incorporating acetoxybenzamide, triacetoxybenzamide, hydroxybenzamide, and trihydroxybenzamide and possessing thiazole, pyrimidine, pyridine, isoxazole and thiadiazole groups were synthesized. Lactoperoxidase (LPO, E.C.1.11.1.7), as a natural antibacterial agent, is a peroxidase enzyme secreted from salivary, mammary, and other mucosal glands. In the present study, the in vitro inhibitory effects of some secondary sulfonamide derivatives (4a–8h) were examined against LPO. The obtained results reveal that secondary sulfonamide derivatives (4a–8h) are effective LPO inhibitors. The Ki values of secondary sulfonamide derivatives (4a–8h) were found in the range of 1.096 × 10−3 to 1203.83 µM against LPO. However, the most effective inhibition was found for N-(sulfathiazole)-3,4,5-triacetoxybenzamide (6a), with Ki values of 1.096 × 10−3 ± 0.471 × 10−3 µM as non-competitive inhibition. |
| Anahtar Kelimeler |
| lactoperoxidase | secondary sulfonamide | enzyme purification | enzyme inhibition |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 41 |
| Google Scholar | 49 |