Biological and computational evaluation of novel benzofuranyl derivatives asacetylcholinesterase and butyrylcholinesterase inhibitors
Yazarlar (5)
Dr. Öğr. Üyesi Hande USANMAZ Sinop Üniversitesi, Türkiye
Arş. Gör. Ömer Taş Türkiye
Deniz Ekinci Türkiye
Ufuk Atmaca Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | FUTURE MEDICINAL CHEMISTRY (Q2) | ||
| Dergi ISSN | 1756-8919 Dergi Bilgileri (2024) | ||
| Dergi Tarandığı Indeksler | SSCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2024 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 30-05-2024 |
| Cilt / Sayı / Sayfa | 16 / 11 / 1075–1085 | DOI | 10.1080/17568919.2024.2342641 |
| Makale Linki | https://www.tandfonline.com/doi/epdf/10.1080/17568919.2024.2342641?needAccess=true | ||
| UAK Araştırma Alanları |
Biyokimya
Organik Kimya
Spektroskopi
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| Özet |
| Aim A highly efficient one-step method has been developed for the synthesis of benzofuranyl derivatives from 2-benzoylcyclohexane-1-carboxylic acid derivatives using chlorosulfonyl isocyanate. This novel method provides a practical, cost-effective and efficient approach. Materials & methods The inhibitory effects of benzofuranyl derivatives on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes were investigated. Ki values were determined to range from 0.009 to 0.61 μM for AChE and 0.28 to 1.60 μM for BChE. Molecular docking analysis provided insights into the interaction modes and binding patterns of these compounds with AChE and BChE. Conclusion Kinetic findings of our study suggest that some of our compounds exhibited more effective low micromolar inhibition compared with the reference, and these derivatives could be used to design more powerful agents. |
| Anahtar Kelimeler |
| acetylcholinesterase | Alzheimer's disease | benzofuranyl | butyrylcholinesterase | molecular modeling |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 3 |
| Google Scholar | 4 |