Biological Activity Studies Of Some Synthesized Novel Furan And Pyran Derivatives
Yazarlar (5)
Esma Sari
Ankara Üniversitesi, Türkiye
Ankara Üniversitesi, Türkiye
Dr. Öğr. Üyesi Hakan ASLAN Sinop Üniversitesi, Türkiye
Dr. Öğr. Üyesi Şeyma Dadi Gazi Üniversitesi, Türkiye
Atilla Öktemer
Ankara Üniversitesi, Türkiye
Ankara Üniversitesi, Türkiye
Elif Loğoğlu Gazi Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SCOPUS dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Gazi University Journal of Science | ||
| Dergi ISSN | 2147-1762 Dergi Bilgileri (2017) | ||
| Dergi Tarandığı Indeksler | ESCI | ||
| Makale Dili | Ingilizce | Basım Tarihi | 12-2017 |
| Cilt / Sayı / Sayfa | 30 / 4 / 49–55 | DOI | – |
| UAK Araştırma Alanları |
Organik Kimya
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| Özet |
| In this study, somenovel furan and pyran derivatives 1-[4-(1-hydroxyethyl)-2-methyl-5-phenyl-4,5dihydrofuran-3-il]ethanone (1);1-(4-Hydroxymethyl-5,5-dimethyl-2-phenyl-4,5-dihydro-furan-3-il)ethanone(2); Ethyl 2-methyl-5-phenyl-5-styryl-4,5-dihydro-furan-3-carboxylate(3); Ethyl4-hydroxymethyl-2,5,5-trimethyl-4,5-dihydro-furan-3-carboxylate (4); Ethyl4-(1-hydroxy-ethyl)-2-methyl-5-phenyl-4,5-dihydro-furan-3-carboxylate (5) Ethyl5-hydroxy-2,6,6-trimethyl-5,6-dihydro-4H-pyran-3-carboxylate (6) were synthesizedas mentioned in our previous report [1].The in vitro novelfuran and pyran derivatives were investigated for antibacterial activityagainst gram-positive bacteria i.e. Bacillus licheniformis M30 , Bacillusmegaterium M22, Bacillus circulans M34, Bacillus subtilis B1, Bacillus subtilis M33 , Bacillus cereus B9, Staphylococcus aureus ATCC 653, Micrococcus luteus M3 and gram-negativei.e. Escherichia coli ATCC 25922 , and as a fungus Pseudomonasaeruginosa P7. The antibacterial and antifungal activities were determined bythe disc diffusion method (DISC) and minimum inhibition concentration (MIC)against the tested gram-positive and gram-negative bacteria and fungus. Theinhibition zones were compared with those of reference discs which were studiedin our previous work [2]. Reference discs used for control were as followsketoconazole, ampicillin, tetracycline, penicillin, chloramphenicol, andgentamicin. From the results it could be said that some of the chemicalcompound can be used as a raw medicine sources. Their antibiogram tests showed better results than some knownantibiotics. |
| Anahtar Kelimeler |
| Antibacterial activity | Antifungal activity | Furan | Pyran |
