Nanoemulsion Hydrogel Delivery System of Hypericum perforatum L.: In Silico Design, In Vitro Antimicrobial–Toxicological Profiling, and In Vivo Wound-Healing Evaluation
Yazarlar (8)
Dr. Öğr. Üyesi Ahmet Arif Kurt Türkiye
Bashar Ibrahım Türkiye
Dr. Öğr. Üyesi Harun Çınar Türkiye
Doç. Dr. Ayşe Nilhan Atsü Türkiye
Dr. Öğr. Üyesi Ertuğrul Osman BURSALIOĞLU Sinop Üniversitesi, Türkiye
Dr. Öğr. Üyesi İsmail Bayır Türkiye
Prof. Dr. Özlem Özmen Türkiye
Doç. Dr. İsmail Aslan Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
|
||
| Dergi Adı | GELS (Q1) | ||
| Dergi ISSN | 2310-2861 Dergi Bilgileri (2025) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2025 |
| Cilt / Sayı / Sayfa | 11 / 6 / 431–0 | DOI | 10.3390/gels11060431 |
| Makale Linki | https://www.mdpi.com/2310-2861/11/6/431 | ||
| UAK Araştırma Alanları |
Biyoteknoloji
|
||
| Özet |
| Hypericum perforatum L.(HP), a plant renowned for its wound-healing properties, was investigated for antioxidant/antimicrobial efficacy, toxicological safety, and in vivo wound-healing effects in this research to develop and characterize novel nanoemulsion hydrogel (NG) formulations. NG were prepared via emulsion diffusion–solvent evaporation and polymer hydration using Cremophor RH40 and Ultrez 21/30. A D-optimal design optimized oil/surfactant ratios, considering particle size, PDI, and drug loading. Antioxidant activity was tested via DPPH, ABTS+, and FRAP. Toxicological assessment followed HET-CAM (ICH-endorsed) and ICCVAM guidelines. The optimized NG-2 (NE-HPM-10+ U30 0.5%) demonstrated stable and pseudoplastic flow, with a particle size of 174.8 nm, PDI of 0.274, zeta potential of− 23.3 mV, and 99.83% drug loading. Release followed the Korsmeyer–Peppas model. HP macerates/NEs … |
| Anahtar Kelimeler |
| hydrogel | nanoemulsion | wound healing | HET-CAM | drug delivery systems | antimicrobial activity | |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 9 |