The Δ32 Allele Distribution of the CCR5 Gene and its Relationship with Certain Cancers in a Turkish Population
Yazarlar (3)
Prof. Dr. Naci Değerli Cumhuriyet Üniversitesi, Türkiye
Doç. Dr. Emire ELMAS Türkiye
Prof. Dr. Fevzi Bardakcı Adnan Menderes Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | CLINICAL BIOCHEMISTRY (Q1) | ||
| Dergi ISSN | 0009-9120 Dergi Bilgileri (2005) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2005 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-03-2005 |
| Cilt / Sayı / Sayfa | 38 / 3 / 248–252 | DOI | 10.1016/j.clinbiochem.2004.11.001 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S0009912004003017 | ||
| UAK Araştırma Alanları |
Ekoloji
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| Özet |
| OBJECTIVE In the present study, we determined the frequency of Δ32 allele distribution and its relationship with various carcinomas in a Turkish population. DESIGN AND METHODS We determined the allelic frequency of CCR5-Δ32 in 267 healthy individuals as well as 39 breast, 34 laryngeal, 30 thyroid and 20 brain carcinomas in a Turkish population using polymerase chain reaction (PCR). RESULTS The frequency of mutant Δ32 alleles in the Turkish population was 2.18%. The population was in the Hardy–Weinberg equilibrium. The frequency of the mutant allele was the highest in patients with breast carcinoma (3.85%) among all the carcinomas studied, but there was no statistically significant relationship (P = 0.334). CONCLUSION The frequency of the Δ32 allele detected in the Turkish population was slightly lower in comparison with the previous reports. The frequency of heterozygote genotypes remained … |
| Anahtar Kelimeler |
| receptor | CCR5-Delta 32 allele | cancer | genetic polymorphism | Turkish |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 29 |
| Google Scholar | 53 |