Evaluation of diffuse lymphadenopathy via various quantitative PET/CT parameters
Yazarlar (3)
Güler Silov
Gazi State Hospital, Samsun, Türkiye
Gazi State Hospital, Samsun, Türkiye
Prof. Dr. Emel ÇANKAYA Sinop Üniversitesi, Türkiye
Seyhan Karaçavuş
University Of Health Sciences, Antigua ve Barbuda
University Of Health Sciences, Antigua ve Barbuda
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Hellenic Journal of Nuclear Medicine (Q4) | ||
| Dergi ISSN | 1790-5427 Dergi Bilgileri (2023) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 04-2023 |
| Cilt / Sayı / Sayfa | 26 / 1 / 47–56 | DOI | 10.1967/s002449912555 |
| Makale Linki | https://pubmed.ncbi.nlm.nih.gov/37031422/ | ||
| UAK Araştırma Alanları |
Uygulamalı İstatistik
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| Özet |
| ObjectiveDiscovery of diffuse lymphadenopathy (DLAP) in fluorine-18-fluorodeoxyglucose (18 F-FDG) positron emission tomography/computed tomography (PET/CT) imaging alerts for the existence of many pathologic conditions with severity ranging from benign to malignancy. This study examines the role of various metabolic parameters reflecting 18 F-FDG characteristics of organs/tissues to reach an accurate differential diagnosis for further clinical assessment.Materials and methodsPositron emission tomography/CT images of 78 patients with DLAP were reviewed retrospectively. The diameter of the largest lymph node (DLlyn), maximum standardized uptake value (SUVmax) of the liver (L), the largest lymph node (Llyn), spleen (S), and bone marrow (BM) were measured. Ratios to liver SUVmax were calculated for all, resulting LLRmax, SLRmax, and BMLRmax respectively.ResultsThe diameter of the largest lymph node, Llyn. SUVmax, LLRmax, and SLRmax produced cut-off values as 25.5, 8.86, 2.80, and 0.82 with corresponding sensitivity: specificity values as 65%: 83%, 74%: 77%, 74%: 71%, and 79%: 63% respectively for risk stratification of malignant causes. To differentiate lymphoma from sarcoidosis, DLlyn, SLRmax, and BMLRmax were found valuable with cut-off values obtained as 28.5, 0.84, and 1.19 with corresponding sensitivity: specificity values as 79%: 91%, 79%: 82%, and 54%: 91%, respectively. Interdependency between parameters was also evaluated.ConclusionHigh values of Llyn. Maximum SUV and LLRmax are the main characteristics of lymphoma, metastasis, and sarcoidosis. The diameter of the largest lymph node … |
| Anahtar Kelimeler |
| F-18-FDGPET/CT | Diffuse lymphadenopathy | Lymphoma | Sarcoidosis | Metastasis | Infection/inammation |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Scopus | 1 |
| Google Scholar | 1 |