Dose-dependent effects of prenatal exposure of pioglitazone, the PPARγ agonist, on the hippocampus development and learning and memory performance of rat offspring
Yazarlar (1)
Doç. Dr. Dilek SAĞIR Sinop Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Toxicology and Applied Pharmacology (Q1) | ||
| Dergi ISSN | 0041-008X Dergi Bilgileri (2021) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2021 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-06-2021 |
| Cilt / Sayı / Sayfa | 421 / 1 / 1–7 | DOI | 10.1016/j.taap.2021.115544 |
| Makale Linki | https://www.sciencedirect.com/science/article/pii/S0041008X21001514 | ||
| UAK Araştırma Alanları |
Hücre Biyolojisi
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| Özet |
| It is known that pioglitazone, defined as a PPARγ agonist, has neuron-protective properties in nervous system disorders. The aim of this study is to investigate the effects of pioglitazone administration at different doses during prenatal period on the neurons, glial cells and learning-memory levels in the hippocampus of rat offspring.Pregnant rats were divided into three groups; Low-Dose Pioglitazone (LDP), High-Dose Pioglitazone (HDP) and control (C) (n = 3). Pregnant rats in the HDP and LDP groups were given pioglitazone at 30 mg/kg and 5 mg/kg doses, respectively, by gavage once a day during their pregnancy. No procedure was applied to the rats in the control group. Morris water tank test was applied to offspring obtained from postnatal 24th to 28th day. The offspring were sacrificed on the 29th postal day and their brain tissues removed. Stereological, histopathological and immunohistochemical techniques … |
| Anahtar Kelimeler |
| Glial fibrillar acidic protein (GFAP) | Hippocampus | Learning and memory | Neurotoxicity | Pioglitazone | PPARγ |
Science Direct
Dose-dependent effects of prenatal exposure of pioglitazone, the PPARγ agonist, on the hippocampus development and learning and memory performance of rat offspring
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 2 |
| Scopus | 2 |
| Google Scholar | 3 |