Stereological examination of curcumin’s effects on hippocampal damage caused by the anti-epileptic drugs phenobarbital and valproic acid in the developing rat brain
Yazarlar (5)
Dr. Öğr. Üyesi Burcu Demirel Yılmaz Ordu Üniversitesi, Türkiye
Banu Eren Ondokuz Mayis Üniversitesi, Türkiye
Doç. Dr. Dilek SAĞIR Sinop Üniversitesi, Türkiye
Zafer Eren Ondokuz Mayis Üniversitesi, Türkiye
Ayşe Başardı Gökçe Ondokuz Mayis Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Acta Histochemica (Q4) | ||
| Dergi ISSN | 0065-1281 Dergi Bilgileri (2019) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 05-2019 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-05-2019 |
| Cilt / Sayı / Sayfa | 121 / 4 / 430–436 | DOI | 10.1016/j.acthis.2019.03.007 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S0065128119300959 | ||
| UAK Araştırma Alanları |
Hücre Biyolojisi
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| Özet |
| The anti-epileptic drugs phenobarbital and valproic acid have an extremely strong negative effect on cognitive processes such as learning and memory in the developing brain. We examined whether or not curcumin has protective effects on neuronal injury caused by these drugs in the developing rat brain. Young male Wistar rats were studied in two groups, a 7 days old and a 14 days old group (35 rats in each). Both groups were then divided into 7 sub-groups as the control, curcumin, dimethylsulfoxide, phenobarbital, valproic acid, phenobarbital + curcumin, and valproic acid + curcumin groups (n = 5 in each group). At 24 h after the intraperitoneal injection of the compounds, the rats were sacrificed, and the hippocampal tissue was subjected to stereological analysis with the optical fractionation method. Total numbers of neurons in the hippocampus of the 7 days old and 14 days old rats were calculated. It … |
| Anahtar Kelimeler |
| Curcumin | Hippocampus | Phenobarbital | Stereology | Valproic acid |
Science Direct
Stereological examination of curcumin’s effects on hippocampal damage caused by the anti-epileptic drugs phenobarbital and valproic acid in the developing rat brain
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 3 |
| Scopus | 3 |
| Google Scholar | 7 |