The Effects of folic acid and topiramate on peripheral nerve regeneration
Yazarlar (4)
Doç. Dr. Dilek SAĞIR Sinop Üniversitesi, Türkiye
E. Kuruoğlu
Ondokuz Mayis Üniversitesi, Türkiye
Ondokuz Mayis Üniversitesi, Türkiye
M. E. Onger
Ondokuz Mayis Üniversitesi, Türkiye
Ondokuz Mayis Üniversitesi, Türkiye
E. Yarar
Bafra State Hospital, Türkiye
Bafra State Hospital, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Biotechnic and Histochemistry (Q4) | ||
| Dergi ISSN | 1052-0295 Dergi Bilgileri (2020) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2020 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 19-08-2019 |
| Cilt / Sayı / Sayfa | 95 / 2 / 105–112 | DOI | 10.1080/10520295.2019.1637022 |
| Makale Linki | https://www.tandfonline.com/doi/full/10.1080/10520295.2019.1637022 | ||
| UAK Araştırma Alanları |
Hücre Biyolojisi
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| Özet |
| Peripheral nerve injury creates unusual sensitivity and pathological spontaneous activity in neurons that are described as ectopic discharge. Voltage dependent Na channels are responsible for ectopic discharge. Topiramate (TOP) inhibits voltage-gated sodium channels by blocking both the amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)/kainate receptor and folic acid (FA) activity in neurotransmitter synthesis reactions. FA and TOP are anti-apoptotic agents by both phosphorylated-Akt (p-Akt) signaling activation and anti-inflammatory effects at the injury site. We investigated the effects of FA and TOP in peripheral nerve injury. We used rats with a sciatic nerve injury (SNI) treated with FA or TOP once daily for 6 weeks. Histological and electrophysiological tests were used to evaluate the morphology, and motor and sensory functions. Numbers of axons, myelin sheath thickness and axon area were … |
| Anahtar Kelimeler |
| Folic acid | peripheral nerve | regeneration | stereology | topiramate |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 6 |
| Scopus | 5 |
| Google Scholar | 8 |