A histopathological and stereological study of the effects of acetylsalicylic acid on doxorubicin-induced hepatotoxicity in mice
Yazarlar (4)
Ayşe Başardı Gökçe Ondokuz Mayis Üniversitesi, Türkiye
Banu Eren Ondokuz Mayıs Üniversitesi, Türkiye
Doç. Dr. Dilek SAĞIR Sinop Üniversitesi, Türkiye
Burcu Demirel Yılmaz Ordu Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Biotechnic and Histochemistry (Q4) | ||
| Dergi ISSN | 1052-0295 Dergi Bilgileri (2020) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2020 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 09-07-2020 |
| Cilt / Sayı / Sayfa | 96 / 1 / 1–6 | DOI | 10.1080/10520295.2020.1788724 |
| Makale Linki | https://www.tandfonline.com/doi/full/10.1080/10520295.2020.1788724 | ||
| UAK Araştırma Alanları |
Hücre Biyolojisi
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| Özet |
| Doxorubicin (Dox) is an anthracycline antibiotic with antineoplastic activity. Acetylsalicylic acid (Asa) is recommended for use as a prophylactic for thromboembolism during treatment of cancers. We investigated liver toxicity due to combined use of Dox and Asa in chemotherapy regimens. We used 140 Swiss albino mice divided into four main groups: control, Dox, Asa, and Dox + Asa. Each group was subdivided into seven subgroups based on time of sacrifice, i.e., 6, 12, 24, 48 h and 7, 14, 21 days. Quantitative and histopathological changes in liver were assessed by light microscopy and stereology. The portal triad area of the Dox and Dox + Asa groups was increased significantly compared to controls at 6 h, whereas in the Asa group, the means were similar to controls. Assessment of histopathology indicated an increased time-dependent degeneration and necrosis of liver tissues in mice in the Dox and Dox + Asa … |
| Anahtar Kelimeler |
| Acetylsalicylic acid | doxorubicin | histopathology | liver | mice | stereology |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 2 |
| Scopus | 2 |
| Google Scholar | 4 |