Inhibition of acrolein-induced apoptosis by the antioxidant selenium
Yazarlar (4)
Ayşe Başardı Gökçe Ondokuz Mayis University Faculty Of Science And Arts, Türkiye
Banu Eren Ondokuz Mayıs Üniversitesi, Türkiye
Doç. Dr. Dilek SAĞIR Sinop Üniversitesi, Türkiye
Burcu Demirel Yılmaz Ordu Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Toxicology and Industrial Health (Q3) | ||
| Dergi ISSN | 0748-2337 Dergi Bilgileri (2020) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2020 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-02-2020 |
| Cilt / Sayı / Sayfa | 36 / 2 / 84–92 | DOI | 10.1177/0748233720909043 |
| Makale Linki | https://journals.sagepub.com/doi/abs/10.1177/0748233720909043 | ||
| UAK Araştırma Alanları |
Hücre Biyolojisi
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| Özet |
| In this study, the effects of a potent antioxidant, selenium, on apoptosis induced by acrolein, a cytotoxic and genotoxic environmental pollutant, were investigated by immunohistochemical and electron microscopic methods. One hundred adult male Wistar albino rats were used in the study. The rats were divided into four main groups: control, acrolein, selenium, and acrolein + selenium. The animals in the experimental groups were given 1 mg/kg/day selenium and 4 mg/kg/day acrolein daily for 7 days by gavage. After drug administration, each group was divided into subgroups according to the time they were to be euthanized: 12th hour, 1st, 2nd, 3rd, and 5th day. The rats in each group at the determined time were euthanized and their livers were removed. Routine histological procedures were performed for light and electron microscopy examinations. After applying the Terminal Deoxynucleotidyl Transferase dUTP … |
| Anahtar Kelimeler |
| Acrolein | apoptosis | histopathology | liver | rat | selenium |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 4 |
| Scopus | 5 |
| Google Scholar | 6 |