Effects of prenatal PPAR-γ agonist rosiglitazone exposure on rat hippocampus development in a time-dependent manner: A stereological and histopathological study
Yazarlar (6)
Doç. Dr. Dilek SAĞIR Sinop Üniversitesi, Türkiye
B. Eren
Ondokuz Mayis University Faculty of Science And Arts, Türkiye
Ondokuz Mayis University Faculty of Science And Arts, Türkiye
B. D. Yılmaz Ordu Üniversitesi, Türkiye
Z. Eren
Ondokuz Mayis University Faculty of Science And Arts, Türkiye
Ondokuz Mayis University Faculty of Science And Arts, Türkiye
O. N. Keleş
Ataturk University, Faculty of Medicine, Türkiye
Ataturk University, Faculty of Medicine, Türkiye
A. B. Gökçe
Ondokuz Mayis University Faculty of Science And Arts, Türkiye
Ondokuz Mayis University Faculty of Science And Arts, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Human and Experimental Toxicology (Q3) | ||
| Dergi ISSN | 0960-3271 Dergi Bilgileri (2017) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2017 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 13-10-2017 |
| Cilt / Sayı / Sayfa | 37 / 8 / 827–835 | DOI | 10.1177/0960327117730883 |
| Makale Linki | https://doi.org/10.1177/0960327117730883 | ||
| UAK Araştırma Alanları |
Hücre Biyolojisi
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| Özet |
| Rosiglitazone is in the thiazolidinedione class of drugs used in the treatment of type 2 diabetes mellitus. It works as an insulin sensitizer by binding to the peroxisome proliferator–activated receptor gamma. We investigated the effects of prenatally administered rosiglitazone on pyramidal cell numbers and morphologies in the hippocampus at postnatal period using histochemical and stereological techniques, congenital morphological properties and the number of offspring in rats. Eighteen female rats were grouped into control (C), low-dose rosiglitazone (LDR) and high-dose rosiglitazone (HDR). LDR pregnant rats received 2 mg/kg/day of rosiglitazone via oral gavage during the first 16 days of the pregnancy. HDR rats received 5 mg/kg/day. The infants were grouped into newborn (NB), 4 week (4 W) and 12 week (12 W). A side from histopathologic and congenital assessments, stereological analyses were … |
| Anahtar Kelimeler |
| hippocampus | neurogenesis | PPAR-γ | Rosiglitazone | stereology |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 8 |
| Scopus | 7 |
| Google Scholar | 10 |