Luteolin mitigates hippocampal damage in a rat model of streptozotocin-induced diabetes
Yazarlar (5)
Ömür Gülsüm Deniz Abant Izzet Baysal University, Faculty Of Medicine, Türkiye
Dr. Öğr. Üyesi Hayriye Soytürk Bolu Abant Izzet Baysal Üniversitesi, Türkiye
Prof. Dr. Aydın Him Abant Izzet Baysal University, Faculty Of Medicine, Türkiye
Doç. Dr. Dilek SAĞIR Sinop Üniversitesi, Türkiye
Doç. Dr. Ebru Annaç Adiyaman Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Biomolecules and Biomedicine (Q3) | ||
| Dergi ISSN | 2831-0896 Dergi Bilgileri (2025) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 05-2025 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 05-05-2025 |
| Cilt / Sayı / Sayfa | 25 / 10 / 2370–2384 | DOI | 10.17305/bb.2025.12305 |
| Makale Linki | https://doi.org/10.17305/bb.2025.12305 | ||
| UAK Araştırma Alanları |
Hücre Biyolojisi
Moleküler Biyoloji
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| Özet |
| Diabetes mellitus (DM) is a chronic metabolic disorder that poses a serious threat to human health by causing long-term damage to various vital organs. It leads to insulin resistance and disrupts carbohydrate, fat, and protein metabolism. This study aimed to investigate the protective effects of luteolin (Lut) against diabetes-induced damage in the hippocampus of rats, using immunohistochemical, histopathological, biochemical, and molecular approaches. Lut [20 µg/kg, intraperitoneally (i.p.)] was administered to counteract hippocampal damage induced by diabetes, which was experimentally triggered using streptozotocin at a dose of 50 mg/kg (i.p.). The experiment lasted 28 days and included 48 rats divided into six groups of eight: Control, DM, citrate buffer (solvent), DM+Lut, Lut, and dimethyl sulfoxide (solvent). In the DMgroup, there was a decrease in Bcl-2 gene expression and an increase in the expression … |
| Anahtar Kelimeler |
| Diabetes mellitus | endoplasmic reticulum stress | hippocampus | luteolin | neurodegeneration | oxidative stress |
BM Sürdürülebilir Kalkınma Amaçları
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| Google Scholar | 2 |