Facile and Mild Synthesis of Linear and Cyclic Peptides via Thioesters
Yazarlar (6)
Paola Agrigento
Novartis International Ag, İsviçre
Novartis International Ag, İsviçre
Fernando Albericio
Irb Barcelona - Institute For Research İn Biomedicine, İspanya
Irb Barcelona - Institute For Research İn Biomedicine, İspanya
Sylvie Chamoin
Novartis International Ag, İsviçre
Novartis International Ag, İsviçre
Isabelle Dacquignies Novartis International Ag, İsviçre
Dr. Öğr. Üyesi Halil KOÇ Sinop Üniversitesi, Türkiye
Martin Eberle
Novartis International Ag, İsviçre
Novartis International Ag, İsviçre
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Organic Letters (Q1) | ||
| Dergi ISSN | 1523-7060 Dergi Bilgileri (2014) | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2014 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 17-07-2014 |
| Cilt / Sayı / Sayfa | 16 / 15 / 3922–3925 | DOI | 10.1021/ol501669n |
| Makale Linki | http://www.scopus.com/inward/record.url?eid=2-s2.0-84905384525&partnerID=MN8TOARS | ||
| UAK Araştırma Alanları |
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| Özet |
| Thioester-mediated peptide bond formation has recently garnered a lot of attention, most notably in its relevance to condensation of large peptide fragments. Herein, a simple and general ligation method for the preparation of linear and cyclic peptides, starting from peptide thioester, mainly p-chlorophenyl, precursors is reported. The inherent advantages of this method are the low epimerization, reduced dimerization, use of mild reaction conditions, and elimination of superfluous coupling reagents. © 2014 American Chemical Society. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 16 |
| Scopus | 19 |