Ex vivo investigation of betaine and boric acid function as preprotective agents on rat synaptosomes to be treated with Aβ (1–42)
Yazarlar (4)
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Environmental Toxicology (Q1) | ||
| Dergi ISSN | 1520-4081 Dergi Bilgileri (2024) | ||
| Makale Dili | – | Basım Tarihi | 01-2024 |
| Kabul Tarihi | 01-12-2023 | Yayınlanma Tarihi | 18-12-2023 |
| Cilt / Sayı / Sayfa | 39 / 4 / 2138–2149 | DOI | 10.1002/tox.24098 |
| Makale Linki | https://onlinelibrary.wiley.com/doi/abs/10.1002/tox.24098 | ||
| UAK Araştırma Alanları |
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| Özet |
| Recent evidence suggests that ferroptosis, an iron‐dependent cell death process, may be involved in Alzheimer's disease (AD) pathology. The study evaluated the therapeutic potential of betaine and boric acid (BA) pretreatment administered to rats for 21 days in AD. Then, the rats were sacrificed, and morphological and biochemical analyses were performed in brain tissues. Next, an ex vivo AD model was created by applying amyloid‐β (Aβ1‐42) to synaptosomes isolated from the brain tissues. Synaptosomes were analyzed with micrograph images, and protein and mRNA levels of ferroptotic markers were determined. Betaine and BA pretreatments did not cause any morphological and biochemical differences in the brain tissue. However, Aβ (1–42) administration in synaptosomes increased the levels of acyl‐CoA synthetase long chain family member‐4 (ACSL4), transferrin receptor‐1 protein (TfR1 … |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 10 |