Copper(II) complexes of long chain pyrazine-modulated pentapyridyltetraamine ligand: synthesis, structure, anticancer activity, and molecular docking studies
Yazarlar (13)
Rayyat Huseyn Ismayilov
Ministry of Science And Education of The Republic of Azerbaijan, Azerbaycan
Ministry of Science And Education of The Republic of Azerbaijan, Azerbaycan
Sabina Zahid Ismayilova
Ministry of Science And Education of The Republic of Azerbaijan, Azerbaycan
Ministry of Science And Education of The Republic of Azerbaijan, Azerbaycan
Ajdar Akber Medjidov
Ministry of Science And Education of The Republic of Azerbaijan, Azerbaycan
Ministry of Science And Education of The Republic of Azerbaijan, Azerbaycan
Mansura Teyfur Huseynova
Ministry of Science And Education of The Republic of Azerbaijan, Azerbaycan
Ministry of Science And Education of The Republic of Azerbaijan, Azerbaycan
Lala Shahin Guliyeva
Ministry of Science And Education of The Republic of Azerbaijan, Azerbaycan
Ministry of Science And Education of The Republic of Azerbaijan, Azerbaycan
Sahil Zahid Hamidov
Azerbaijan Technological University, Azerbaycan
Azerbaijan Technological University, Azerbaycan
Prof. Dr. Bahattin Yalçin Marmara Üniversitesi, Türkiye
Prof. Dr. Sibel Demir Kanmazalp Marmara Üniversitesi, Türkiye
Prof. Dr. Senem Akkoc Süleyman Demirel Üniversitesi, Türkiye
Prof. Dr. Onur ŞAHİN Sinop Üniversitesi, Türkiye
Su Ying Chien
Academia Sinica, Institute of Chemistry, Tayvan
Academia Sinica, Institute of Chemistry, Tayvan
Gene Hsiang Lee
National Taiwan University, Tayvan
National Taiwan University, Tayvan
Chi How Peng
National Taiwan University, Tayvan
National Taiwan University, Tayvan
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Molecular Structure (Q2) | ||
| Dergi ISSN | 0022-2860 Dergi Bilgileri (2027) | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2027 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-01-2027 |
| Cilt / Sayı / Sayfa | 1379 / 1 / – | DOI | 10.1016/j.molstruc.2026.147295 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S0022286026020491 | ||
| UAK Araştırma Alanları |
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| Özet |
| Two novel mononuclear copper(II) complexes, [Cu(H 4 N 9 -mpz)]Cl 2 ·H 2 O ( 1 ) and [Cu(H 4 N 9 -mpz)](ClO 4 ) 2 ·2CH 3 OH ( 2 ), were synthesized for the first time utilizing the pyrazine-modulated long-chain pentapyridyltetraamine ligand, N 2 ,N 2′ -(pyrazine-2,6-diyl)bis(N 6 -(pyridin-2-yl)pyridine-2,6-diamine) (H 4 N 9 -mpz). Both complexes were structurally characterized, and their in vitro cytotoxic activities were systematically evaluated. In each compound, the Cu(II) center is five-coordinate, adopting a slightly distorted trigonal bipyramidal geometry, with Addison distortion parameter τ values of 0.84 for complex ( 1) and 0.86 for complex ( 2). The H 4 N 9 -mpz ligand adopts an all-anti conformation, coordinating to the copper center as a pentadentate monohelical ligand. This trigonal bipyramidal coordination environment was further corroborated by electronic spectroscopy and the observation of "inverted … |
| Anahtar Kelimeler |
| Cancer | Copper complex | Hydrogen bonds | Modulated oligo-α-pyridylamine ligand | Molecular docking | Supramolecular networks |