Hepatoprotective Effects of Curcumin on Liver Injury in Streptozocin-induced Diabetic Rats
Yazarlar (3)
Doç. Dr. Bilge BAL ÖZKAPTAN Sinop Üniversitesi, Türkiye
Doç. Dr. Dilek SAĞIR Sinop Üniversitesi, Türkiye
Fatma Aksoy Tokat Gaziosmanpaşa Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
|
||
| Dergi Adı | JOURNAL OF THE ANATOMICAL SOCIETY OF INDIA (Q4) | ||
| Dergi ISSN | 0003-2778 Dergi Bilgileri (2024) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 07-2024 |
| Cilt / Sayı / Sayfa | 73 / 3 / 218–226 | DOI | 10.4103/jasi.jasi_55_23 |
| Makale Linki | http://dx.doi.org/10.4103/jasi.jasi_55_23 | ||
| UAK Araştırma Alanları |
Dahili Hastalıklar Hemşireliği
|
||
| Özet |
| Materials and Methods:Thirty-two adult male rats were used in the study. The rats were divided into four groups: Control (C), Diabetes (D), Curcumin (CUR), and Diabetes+ Curcumin (D+ CUR)(n= 8). The groups given curcumin were given 60 mg/kg curcumin by gavage once a day during the 14-day study period. At the end of the experiment, biochemical, stereological, histological, and immunohistochemical analyses were performed on blood and liver samples taken from rats sacrificed.Results:After curcumin treatment in diabetic rats, there was a significant decrease in blood glucose levels, hepatic markers, and levels of thiobarbituric acid reactive substances (P< 0.01). Furthermore, a significant increase in enzymatic antioxidants such as superoxide dismutase, catalase, and glutathione peroxidase was observed after treatment (P< 0.01). It was determined that curcumin decreased the apoptotic index and the … |
| Anahtar Kelimeler |
| Apoptosis | curcumin | diabetes | liver | oxidative stress |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 2 |