Coaction of hepatic thioredoxin and glutathione systems in iron overload-induced oxidative stress
Yazarlar (3)
Feyza Sönmez Aydın
Dr. Öğr. Üyesi Berna HUKKAMLI Sinop Üniversitesi, Türkiye
Prof. Dr. Harun Budak Atatürk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (Q2) | ||
| Dergi ISSN | 1095-6670 Dergi Bilgileri (2021) | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | Türkçe | Basım Tarihi | 04-2021 |
| Cilt / Sayı / Sayfa | 35 / 4 / – | DOI | 10.1002/jbt.22704 |
| Makale Linki | https://pubmed.ncbi.nlm.nih.gov/33393188/ | ||
| UAK Araştırma Alanları |
Genetik
|
||
| Özet |
| In the present study, we demonstrate the coaction of thioredoxin and glutathione (GSH) systems in mouse liver against iron overload‐induced oxidative stress (OS). Mice were injected intraperitoneally with an iron dextran solution twice a week for 3 weeks. Iron accumulation in mouse liver was demonstrated spectroscopically. To confirm the iron overload model in the liver, the increased gene expression levels of hepcidin (Hamp), ferroportin (Fpn1), and ferritin (Fth1), which regulate iron trafficking, were observed by a quantitative polymerase chain reaction. In the case of iron overload, the GSH level and the reduced glutathione/oxidized glutathione ratio, which represents a marker of OS, decreased significantly. An increase in the malondialdehyde level, one of the final products of the lipid peroxidation process, was observed. The gene expression of the thioredoxin system, including thioredoxin (Trx1) and … |
| Anahtar Kelimeler |
| glutathione system | iron overload | mouse liver | oxidative stress | thioredoxin system |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 37 |
| Google Scholar | 52 |