Comparison of the efficacy of the mouse hepatic and renal antioxidant systems against inflammation-induced oxidative stress
Yazarlar (4)
Dr. Öğr. Üyesi Berna HUKKAMLI Sinop Üniversitesi, Türkiye
Arş. Gör. Burak Dağdelen Selçuk Üniversitesi, Türkiye
Feyza Sönmez Aydın
Doğuş Üniversitesi, Türkiye
Doğuş Üniversitesi, Türkiye
Prof. Dr. Harun Budak Atatürk Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | CELL BIOCHEMISTRY AND BIOPHYSICS (Q3) | ||
| Dergi ISSN | 1085-9195 Dergi Bilgileri (2023) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2023 |
| Cilt / Sayı / Sayfa | 81 / 2 / 299–311 | DOI | 10.1007/s12013-023-01126-3 |
| Makale Linki | https://doi.org/10.1007/s12013-023-01126-3 | ||
| UAK Araştırma Alanları |
Genetik
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| Özet |
| This study was conducted to compare the efficacy of the mouse hepatic and renal antioxidant systems against inflammation-induced oxidative stress. Increased Il-1 and Il-6 expressions, markers of inflammation, were represented by inflammation models in mouse liver and kidney tissues injected intraperitoneally with LPS. After establishing the model, the GSH level and the GSH/GSSG ratio, which are oxidative stress markers, were investigated in both tissues treated with LPS and the control group. The expression of Trx1, TrxR, and Txnip genes increased in the liver tissues of LPS-treated mice. In the kidney tissue, while Trx1 expression decreased, no change was observed in TrxR1 expression, and Txnip expression increased. In the kidneys, TRXR1 and GR activities decreased, whereas GPx activity increased. In both tissues, the TRXR1 protein expression decreased significantly, while TXNIP expression … |
| Anahtar Kelimeler |
| Inflammation | Oxidative stress | Thioredoxin system | Glutathione system | Expression and activity |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 5 |
| Google Scholar | 6 |