Synergistic integration of trifluoromethyl and phenolic moieties into novel hydrazone scaffolds: Synthesis, spectroscopic elucidation, and multidimensional antioxidant evaluation
Yazarlar (3)
Doç. Dr. Tolga Acar YEŞİL Sinop Üniversitesi, Türkiye
Öğr. Gör. Ömer Dilek Isparta Uygulamalı Bilimler Üniversitesi, Türkiye
Prof. Dr. Tahir Tilki Süleyman Demirel Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Molecular Structure (Q2) | ||
| Dergi ISSN | 0022-2860 Dergi Bilgileri (2026) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 01-2026 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-10-2026 |
| Cilt / Sayı / Sayfa | 1373 / 1 / – | DOI | 10.1016/j.molstruc.2026.146754 |
| Makale Linki | https://doi.org/10.1016/j.molstruc.2026.146754 | ||
| UAK Araştırma Alanları |
Organik Kimya
Spektroskopi
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| Özet |
| Oxy-radical damage is a central mechanism in various diseases, prompting the search for novel scaffolds with enhanced stability and radical-scavenging efficiency. In this study, we report the design and synthesis of eight novel hydrazone derivatives (3a–h) featuring a synergistic integration of a metabolic-stabilizing trifluoromethyl (-CF 3 ) group and radical-scavenging phenolic hydroxyl moieties. The compounds were synthesized in high yields (80–92%), and FTIR, NMR, and mass spectrometry rigorously elucidated their structures. Crucially, comprehensive 2D COSY and NOESY NMR analyses in DMSO-d 6 using 3a as a representative model confirmed that the synthesized hydrazones exist exclusively in the thermodynamically favored, conformationally rigid E -configuration across the azomethine core. To decode the electronic environment, quantum chemical calculations were conducted using Density … |
| Anahtar Kelimeler |
| Antioxidant activity | Computational drug discovery | Phenolic compounds | Quantum chemical calculations | Trifluoromethylated hydrazones |
Science Direct
Synergistic integration of trifluoromethyl and phenolic moieties into novel hydrazone scaffolds: Synthesis, spectroscopic elucidation, and multidimensional antioxidant evaluation
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Scopus | 1 |
| Google Scholar | 1 |