The relationship between the presence of ADHD and certain candidate gene polymorphisms in a Turkish sample
Yazarlar (11)
Ozan Pazvantoǧlu
Ondokuz Mayis Üniversitesi, Türkiye
Prof. Dr. Sezgin Güneş Ondokuz Mayis Üniversitesi, Türkiye
Koray Karabekiroǧlu
Ondokuz Mayis Üniversitesi, Türkiye
Doç. Dr. Zeynep YEĞİN Sinop Üniversitesi, Türkiye
Zehra Erenkuş
Hacettepe Üniversitesi, Türkiye
Seher Akbaş
Ondokuz Mayis Üniversitesi, Türkiye
Prof. Dr. Gökhan Sarisoy Ondokuz Mayis Üniversitesi, Türkiye
Işil Zabun Korkmaz
Ondokuz Mayis Üniversitesi, Türkiye
Prof. Dr. Ömer Böke Ondokuz Mayis Üniversitesi, Türkiye
Hasan Baǧci
Ondokuz Mayis Üniversitesi, Türkiye
Ahmet Rifat Şahin
Ondokuz Mayis Üniversitesi, Türkiye
Makale Türü Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı Gene (Q3)
Dergi ISSN 0378-1119 Dergi Bilgileri (2013)
Makale Dili İngilizce Basım Tarihi 10-2013
Kabul Tarihi – Yayınlanma Tarihi 01-10-2013
Cilt / Sayı / Sayfa 528 / 2 / 320–327 DOI 10.1016/j.gene.2013.07.004
Makale Linki https://www.sciencedirect.com/science/article/pii/S0378111913008585
UAK Araştırma Alanları
Özet
Due to the high heritability of attention-deficit hyperactivity disorder (ADHD), parents of children with ADHD appear to represent a good sample group for investigating the genetics of the disorder. The aim of this study was to investigate the association between ADHD and six polymorphisms in five candidate genes [5-HT2A (rs6311), NET1 (rs2242447), COMT (rs4818), NTF3 (rs6332), SNAP-25 (rs3746544) and (rs1051312)]. We included 228 parents of children diagnosed with ADHD and 109 healthy parents as the control group. The polymorphisms were genotyped using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) assays and analyzed using the chi-square test and the multinomial logit model. SNAP-25 (rs3746544) polymorphism was associated with loading for ADHD, while 5-HT2A (rs6311) and NET1 (rs2242447) polymorphisms were associated with ADHD. On the …
Anahtar Kelimeler
5-HT2A gene | Genetics of ADHD | NET1 gene | SNAP-25 gene