The relationship between ADHD and norepinephrine transporter gene polymorphism in a genetically loaded population
Yazarlar (10)
Ozan Pazvantoglu
Hasan Bağcı
Ömer Böke
Seher Akbaş
Isil Zabun Korkmaz
Gökhan Sarısoy
Koray Karabekiroğlu
Sezgin Güneş
Ahmet Rifat Şahin
| Makale Türü | Özgün Makale (SCOPUS dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Psychiatry and Clinical Psychopharmacology | ||
| Makale Dili | – | Basım Tarihi | 01-2012 |
| Cilt / Sayı / Sayfa | 22 / 0 / – | DOI | – |
| Makale Linki | https://www.psychiatry-psychopharmacology.com/index.php/pub/article/view/2106 | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| Objective: In this study, we aimed to investigate the relationship between ADHD and norepinephrine transporter gene in a genetically loaded population, including parents of children with ADHD.Method: 228 parents, who have at least one child with ADHD, and healthy (HC) controls (n= 109), without any children suffering ADHD were included in the study. While 108 parents had not taken the ADHD diagnosis [(ADHD (-)] at any time in their lives, 120 of them had a diagnosis of ADHD [(ADHD (+)] once in a lifetime. Genetic analysis was done for NET1 gene rs2242447 genetic polymorphism in peripheral blood samples taken from the participants. The presence of allele rates and allele frequencies between two groups were compared with chi-square test.Results: A significant difference was found between ADHD (+) and ADHD (-) groups in terms of allele frequency (p= 0.005, x2= 7.90, OR= 1.22). While the presence of C allele was higher in ADHD (+) group (p= 0.008, x2= 7.12, OR= 1.45), in ADHD (-) group the presence of T allele was higher rate (p= 0.049, x2= 3.88, OR= 1.41). On the other hand, while the ADHD (+) group had the presence of T allele in a lesser extent compared to HC group (p= 0.029, x2= 4.76, OR= 1.47), ADHD (-) group had the presence of C allele in a lesser extent compared to HC group (p= 0.021, x2= 5.30, OR= 1.40).Conclusions: Results can be interpreted that T allele of the NET1 gene rs2242447 polymorphism is protective for ADHD. On the other hand, High levels of C allele could be a risk factor for ADHD for the parents having children with ADHD. |
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| Google Scholar | 1 |