Morin (2′, 3, 4′, 5, 7-Pentahydroxyflavon) Antioxidant Effect in Streptozotocin-Induced Diabetic Rat Brain and Heart Tissues
Yazarlar (4)
Dr. Öğr. Üyesi Mustafa Orhan ARAL Sinop Üniversitesi, Türkiye
Emine Gülçeri Güleç Peker
Nursel Gül
Prof. Dr. Şule Coşkun Cevher Sinop Üniversitesi
| Makale Türü |
Özgün Makale
(Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale)
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| Dergi Adı | Journal of Anatolian Environmental and Animal Sciences | ||
| Makale Dili | – | Basım Tarihi | 09-2022 |
| Cilt / Sayı / Sayfa | 7 / 3 / 257–262 | DOI | – |
| Makale Linki | https://dergipark.org.tr/en/pub/jaes/article/1103000?issue_id=72468 | ||
| UAK Araştırma Alanları |
Su Ürünleri Yetiştiriciliği
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| Özet |
| Diabetes mellitus is agreed to be among the biggest public health burdens seen at the world. Recently, the using natural products (flavonoids specially) in diabetes treatment witnessed a growing interest due to insulin's and oral anti-diabetic medicines' unfavorable side effects. The present work is studies the beneficial effects of morin (2′,3,4′,5,7-pentahydroxyflavone) on antioxidant of tissues and lipid peroxidation status in diabetic and non-diabetic rats. Diabetes associated with elevation in reactive oxygen species and deficient in antioxidant activity, which is important aspects for pathogenesis of diabetes. The role of morin on the brain and heart antioxidant markers were estimated. The diabetic rats exhibited elevated levels of TBARS, NOx and GSH levels in brain and heart tissues when compared with healthy animals. The treatments using morin significantly stopped elevation in brain and heart TBARS and NOx levels. Oral administration of morin showed significant increase in GSH level in brain tissue. These results indicated that morin exerts antioxidative activity in diabetic rats. |
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