The effect of water on the Fe3+/Fe2+ reduction potential of heme
Yazarlar (6)
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Biochemical and Biophysical Research Communications (Q2) | ||
| Makale Dili | – | Basım Tarihi | 02-2000 |
| Cilt / Sayı / Sayfa | 268 / 3 / 683–687 | DOI | – |
| Makale Linki | https://www.sciencedirect.com/science/article/pii/S0006291X00922010 | ||
| UAK Araştırma Alanları |
Dedektör Teknolojisi
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| Özet |
| Hemeproteins can act as catalysts, oxygen carriers or electron conductors. The ferric/ferrous reduction potential Em7 of iron in the center of the prosthetic group ranges from negative values for peroxidases to an extreme positive value for cytochrome a3 with Hb and Mb in the middle [1]. Proteins exercise their influence on Em7 in several ways: via substituents at the periphery of the chelate structure, via the proximal ligand, and via interaction with the surrounding medium, amino acid side chains, or polar solvents. Work on recombined proteins and 2,4-substituted free hemes documented that the first two effects are additive [2]. For the third effect, models of the dielectric media on a molecular level have been successfully applied [3–5]. Em7 has also been empirically correlated to the degree of heme exposure to water [6–8]. The apoprotein/porphyrin and water/porphyrin interfaces are complementary since water … |
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