The role of IL-1β in aortic aneurysm
Yazarlar (8)
Fan Wenjing
Tang Tingting
Zeng Qian
Wan Hengquan
Prof. Dr. Kamil DEMİRCİ Sinop Üniversitesi, Türkiye
Oware Kwabena Agyare
Jiang Zhisheng
Qu Shunlin
Sinop Üniversitesi
Sinop Üniversitesi
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Clinica Chimica Acta (Q1) | ||
| Makale Dili | – | Basım Tarihi | 05-2020 |
| Cilt / Sayı / Sayfa | 504 / 0 / 7–14 | DOI | – |
| Makale Linki | https://www.sciencedirect.com/science/article/pii/S0009898120300164 | ||
| UAK Araştırma Alanları |
Matematiksel Analiz
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| Özet |
| Interleukin-1β (IL-1β) is a vital cytokine that plays an important role in regulating immune responses to infectious challenges and sterile insults. In addition, two endogenous inhibitors of functional receptor binding, IL-1 receptor antagonist (IL-1Ra), complete the family. To gain biological activity, IL-1β requires processing by the protease caspase-1 and activation of inflammasomes. Numerous clinical association studies and experimental approaches have implicated members of the IL-1 family, their receptors, or components of the processing machinery in the underlying processes of cardiovascular diseases. Here, we summarize the current state of knowledge regarding the pro-inflammatory and disease-modulating role of the IL-1 family in aneurysm. We discuss clinical evidence, signalling pathway, and mechanism of action and last, lend a perspective on currently developing therapeutic strategies involving IL-1β in … |
| Anahtar Kelimeler |
