New 5-methylisatin including thiocarbohydrazones: preparation, structure elucidation and antimicrobial activity
Yazarlar (6)
Doç. Dr. Hasan Yakan Ondokuz Mayis Üniversitesi, Türkiye
Doç. Dr. Şükriye ÇAKMAK Sinop Üniversitesi, Türkiye
Osman Buruk
Ondokuz Mayis Üniversitesi, Türkiye
Ondokuz Mayis Üniversitesi, Türkiye
Doç. Dr. Aysel VEYİSOĞLU Sinop Üniversitesi, Türkiye
Halit Muğlu Kastamonu University, Türkiye
Öğr. Gör. Nalan Türköz Karakullukçu Ondokuz Mayis Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Research on Chemical Intermediates (Q2) | ||
| Dergi ISSN | 0922-6168 Dergi Bilgileri (2022) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 08-2022 |
| Cilt / Sayı / Sayfa | 48 / 1 / 4331–4345 | DOI | 10.1007/s11164-022-04799-2 |
| Makale Linki | http://dx.doi.org/10.1007/s11164-022-04799-2 | ||
| UAK Araştırma Alanları |
Mikrobiyoloji
Bakteriyoloji
Moleküler Biyoloji
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| Özet |
| New 5-methylisatin including thiocarbohydrazones (1–5) have been synthesized. The chemical structure of synthesized compounds was elucidated with IR, 1H NMR, 13C NMR spectroscopic methods, and elemental analysis. Moreover, the synthesized compounds have been screened for antimicrobial activity. Their antibacterial activities were tested against Gram-positive (Bacillus subtilis ATCC 6623, Staphylococcus aureus ATCC 25923, Enterococcus faecalis ATCC 29212), Gram-negative (Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 70060, Pseudomonas aeruginosa ATCC 27853), and fungal (Candida albicans ATCC 10231, Aspergillus niger ATCC 16404) microbial strains using the microdilution method. In the isatin series, particularly the compound 2 showed the best antimicrobial activity against E. faecalis strain with MIC values of 64 μg/mL compared to other compounds. This high activity … |
| Anahtar Kelimeler |
| Antimicrobial activity | Isatin | Minimum inhibitory concentration (MIC) | Schiff bases | Spectroscopic studies | Thiocarbohydrazones |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 8 |
| Scopus | 8 |
| Google Scholar | 11 |