SOX4 expression levels in urothelial bladder carcinoma
Yazarlar (5)
Prof. Dr. Sezgin Güneş Ondokuz Mayıs Üniversitesi, Türkiye
Doç. Dr. Zeynep YEĞİN Sinop Üniversitesi, Türkiye
Prof. Dr. Yurdanur Süllü Ondokuz Mayıs Üniversitesi, Türkiye
Recep Büyükalpelli
Ondokuz Mayıs Üniversitesi, Türkiye
Ondokuz Mayıs Üniversitesi, Türkiye
Arş. Gör. Hasan Bağcı Ondokuz Mayıs Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Pathology Research and Practice (Q3) | ||
| Dergi ISSN | 0344-0338 Dergi Bilgileri (2011) | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2011 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-07-2011 |
| Cilt / Sayı / Sayfa | 207 / 7 / 423–427 | DOI | 10.1016/j.prp.2011.05.005 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S0344033811001191 | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| High levels of SOX4 gene expression have been reported in a variety of human cancers. The protein may function in the apoptosis pathway, leading to cell death as well as to tumorigenesis. The aim of this study was to investigate the levels of SOX4 expression in bladder cancer. Urinary bladder tumor samples were obtained from 57 bladder cancer and 13 normal bladder biopsies. The levels of SOX4 expression in bladder cancer were determined by immunohistochemistry and real-time PCR. SOX4 gene expression was increased 2.2 times in bladder tumors as compared with normal tissue. The presence of protein was confirmed by immunostaining. There were significant differences between immunostaining of bladder tumors and normal bladder tissue (P = 0.001). The present data suggest that SOX4 gene may have a role in bladder cancer tumorigenesis. |
| Anahtar Kelimeler |
| Bladder carcinoma | Gene expression | SOX4 gene |
Science Direct
SOX4 expression levels in urothelial bladder carcinoma
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 21 |
| Scopus | 22 |
| Google Scholar | 30 |