ErbB receptor tyrosine kinase family expression levels in urothelial bladder carcinoma
Yazarlar (6)
Prof. Dr. Sezgin Güneş Ondokuz Mayıs Üniversitesi, Türkiye
Prof. Dr. Yurdanur Süllü Ondokuz Mayıs Üniversitesi, Türkiye
Doç. Dr. Zeynep YEĞİN Sinop Üniversitesi, Türkiye
Recep Büyükalpelli
Ondokuz Mayıs Üniversitesi, Türkiye
Ondokuz Mayıs Üniversitesi, Türkiye
Prof. Dr. Leman Tomak Ondokuz Mayıs Üniversitesi, Türkiye
Arş. Gör. Hasan Bağcı Ondokuz Mayıs Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Pathology Research and Practice (Q3) | ||
| Dergi ISSN | 0344-0338 Dergi Bilgileri (2013) | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2013 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-02-2013 |
| Cilt / Sayı / Sayfa | 209 / 2 / 99–104 | DOI | 10.1016/j.prp.2012.10.014 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S0344033812003044 | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| ErbB receptor tyrosine kinases family plays an important role in cell cycle regulation. Overexpression of ErbB receptors has been described in several solid tumors. The aim of this study was to investigate the levels of ErbB1, ErbB2, ErbB3, and ErbB4 expression in bladder cancer. Urinary bladder tumor samples were obtained from 33 bladder cancers and 7 non-cancerous bladder biopsies. The levels of ErbB1, ErbB2, ErbB3, and ErbB4 genes expression in bladder cancer were determined by real-time PCR. The presence of protein was confirmed by immunostaining. Expression of ErbB1, ErbB2, ErbB3, and ErbB4 genes increased 0.67, 4.72, 2.89, and 2.65-fold, respectively, in bladder tumors as compared with normal tissue. There was a significant difference between immunostaining results of ErbB4 protein in bladder tumors and normal bladder tissue (P<0.01). The present data suggest that ErbB2, ErbB3, and … |
| Anahtar Kelimeler |
| ERBB1-4 gene | Gene expression | Urothelial bladder carcinoma |
Science Direct
ErbB receptor tyrosine kinase family expression levels in urothelial bladder carcinoma
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| Atıf Sayıları | |
| Web of Science | 9 |
| Scopus | 11 |
| Google Scholar | 16 |