Hypermethylation of TWIST1 and NID2 in Tumor Tissues and Voided Urine in Urinary Bladder Cancer Patients
Yazarlar (3)
Doç. Dr. Zeynep YEĞİN Sinop Üniversitesi, Türkiye
Sezgin Güneş Ondokuz Mayıs Üniversitesi, Türkiye
Recep Büyükalpelli
Ondokuz Mayıs Üniversitesi, Türkiye
Ondokuz Mayıs Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | DNA and Cell Biology (Q3) | ||
| Dergi ISSN | 1044-5498 Dergi Bilgileri (2013) | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2013 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-07-2013 |
| Cilt / Sayı / Sayfa | 32 / 7 / 386–392 | DOI | 10.1089/dna.2013.2030 |
| Makale Linki | http://dx.doi.org/10.1089/dna.2013.2030 | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| Bladder cancer like other cancers arises from the accumulation of many genetic and epigenetic changes that lead to the activation of proto-oncogenes or inactivation of tumor suppressor genes. We aimed to investigate the methylation patterns of Twist homolog 1 (TWIST1) and nidogen-2 (NID2) genes in bladder cancer. Fifty six histologically confirmed bladder tumor samples and paired 24 urine samples constituted the study group and was compared with 15 age- and gender-matched noncancerous individuals. DNA was purified from both tumor and urine samples. The methylation status of the two genes was analyzed by methylation-specific polymerase chain reaction (MSP) in both urinary bladder cell carcinoma samples and urine samples. Sensitivity and specificity values of the method were assessed and compared with the results of the cytology test. Methylation of TWIST1 and NID2 was detected in 98.2% and … |
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BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 39 |
| Scopus | 44 |
| Google Scholar | 54 |