Expression of GRP78 and its copartners in HEK293 and pancreatic cancer cell lines (BxPC-3/PANC-1) exposed to MRI and CT contrast agents
Yazarlar (4)
Ali Ahmed Azzawri
Selçuk Üniversitesi, Türkiye
Selçuk Üniversitesi, Türkiye
İbrahim Halil Yıldırım Dicle Üniversitesi, Türkiye
Doç. Dr. Zeynep YEĞİN Sinop Üniversitesi, Türkiye
Abdürrahim Dusak
Harran Üniversitesi, Türkiye
Harran Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Nucleosides Nucleotides and Nucleic Acids (Q4) | ||
| Dergi ISSN | 1525-7770 Dergi Bilgileri (2023) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2023 |
| Kabul Tarihi | 21-09-2023 | Yayınlanma Tarihi | 03-10-2023 |
| Cilt / Sayı / Sayfa | 43 / 5 / 391–416 | DOI | 10.1080/15257770.2023.2263496 |
| Makale Linki | https://www.tandfonline.com/doi/full/10.1080/15257770.2023.2263496?src= | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| Endoplasmic reticulum (ER) stress-associated chaperones trigger a defense mechanism called as unfolded protein response (UPR) which can manage apoptosis and be determinative in cell fate. Both anticancer drug effects and potential toxicity effects of magnetic resonance imaging (MRI) and computed tomography (CT) contrast agents were aimed to be evaluated. For this purpose, we investigated expression profiles of endoplasmic reticulum stress-associated chaperone molecules in human pancreatic tumor lines BxPC-3 and PANC-1 and control human embryonic kidney cells 293 (HEK293) induced with a variety of gadolinium and iohexol contrast agents. Protein expression levels of ER stress-associated chaperones (master regulator: GRP78/Bip and its copartners: Calnexin, Ero1, PDI, CHOP, IRE1α and PERK) were evaluated with Western blotting. Expression levels at mRNA level were also assessed for … |
| Anahtar Kelimeler |
| endoplasmic reticulum stress | gadolinium | GRP78/bip | iohexol | Pancreatic cancer | unfolded protein response |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Scopus | 1 |
| Google Scholar | 1 |