For whom the circadian clock ticks? Investigation of PERIOD and CLOCK gene variants in bipolar disorder
Yazarlar (4)
Doç. Dr. Zeynep YEĞİN Sinop Üniversitesi, Türkiye
Prof. Dr. Gökhan Sarısoy Ondokuz Mayıs Üniversitesi, Türkiye
Ayşe Ergüner Aral
Ondokuz Mayis University, Medical School, Türkiye
Ondokuz Mayis University, Medical School, Türkiye
Doç. Dr. Haydar Koç Çankırı Karatekin Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Chronobiology International (Q2) | ||
| Dergi ISSN | 0742-0528 Dergi Bilgileri (2021) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 06-2021 |
| Kabul Tarihi | 09-04-2021 | Yayınlanma Tarihi | 10-06-2021 |
| Cilt / Sayı / Sayfa | 38 / 8 / 1109–1119 | DOI | 10.1080/07420528.2021.1917594 |
| Makale Linki | http://dx.doi.org/10.1080/07420528.2021.1917594 | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| Clock genes play significant roles in the regulation of circadian rhythms, which are thought to be involved in the pathophysiology of neurodegenerative and psychiatric diseases. We aimed to investigate the association of five gene polymorphisms (PER3 VNTR (rs57875989), PER2 rs2304672, CLOCK rs1801260, CLOCK rs10462028, CLOCK rs11932595) with PCR-based methods as potential risk factors in bipolar disorder (BD). We used a multiple testing methodology in BD patients (n = 121) and healthy control individuals (n = 121) of Turkish descent to analyze the effects of these gene variants both as risk factors for the disorder and for the evaluation of these variants in the patient group with multiple subscales. We evaluated the circadian rhythm disturbances and seasonal variations in mood and behavior in BD patients using the Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN) and … |
| Anahtar Kelimeler |
| Bipolar disorder | circadian clock | CLOCK gene | PER2 gene | PER3 gene |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 9 |
| Scopus | 14 |
| Google Scholar | 18 |