Role of miRNA gene variants (miR-22 and miR-155) as the factors affecting susceptibility to panic disorder
Yazarlar (4)
Doç. Dr. Zeynep YEĞİN Sinop Üniversitesi, Türkiye
Prof. Dr. Gökhan Sarısoy Ondokuz Mayıs Üniversitesi, Türkiye
Prof. Dr. Ahmet Uzun Ondokuz Mayis University, Medical School, Türkiye
Doç. Dr. Haydar Koç Çankırı Karatekin Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Clinical Psychopharmacology and Neuroscience (Q2) | ||
| Dergi ISSN | 1738-1088 Dergi Bilgileri (2024) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 11-2024 |
| Kabul Tarihi | 18-07-2024 | Yayınlanma Tarihi | 28-08-2024 |
| Cilt / Sayı / Sayfa | 22 / 4 / 655–661 | DOI | 10.9758/cpn.24.1201 |
| Makale Linki | https://www.cpn.or.kr/journal/view.html?uid=1693&vmd=Full | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| Objective Variants within genes encoding microRNAs (miRNAs) may alter the expression of both miRNAs and their target genes, thus contributing to the etiology of psychiatric disorders. The involvement of miRNAs in neuronal differentiation and synaptic plasticity supported this hypothesis. We aimed to investigate the links between miR-155 rs767649/miR-22 rs8076112 and the risk of panic disorder (PD) in a sample of Turkish population. Methods In this experimental study, 134 PD patients and 140 healthy controls were recruited. Genotyping was carried out using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method. To evaluate PD phenotypes, Panic Disorder Severity Scale (PDSS) was also administered to patients to clarify possible associations between the scale and risk variants analyzed. Results The genotype analysis of miR-155 rs767649 did not show an … |
| Anahtar Kelimeler |
| Genetic association | MicroRNA | miR-155 | miR-22 | Panic disorder | Panic Disorder Severity Scale |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 2 |
| Scopus | 2 |
| Google Scholar | 2 |