Thymoquinone Down-regulates VEGFA and Up-regulates FLT1 Transcriptional Levels in Human Breast Cancer Cells
Yazarlar (3)
Doç. Dr. Zeynep YEĞİN Sinop Üniversitesi, Türkiye
Doç. Dr. Tuğçe Duran Kto Karatay Üniversitesi, Türkiye
İbrahim Halil Yıldırım Dicle Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | INTERNATIONAL JOURNAL OF HUMAN GENETICS (Q4) | ||
| Dergi ISSN | 0972-3757 Dergi Bilgileri (2020) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2020 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 02-01-2020 |
| Cilt / Sayı / Sayfa | 20 / 1 / 19–24 | DOI | 10.31901/24566330.2020/20.01.746 |
| Makale Linki | http://dx.doi.org/10.31901/24566330.2020/20.01.746 | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| Angiogenesis is important for cancer progression index and angiogenesis factors related to tumorogenesis deserve to be investigated in detail. The use of minimally toxic phytochemical compounds as the new generation anticancer agents is an appreciated approach to manage angiogenesis factors. The purpose of this study was to investigate the potential effects of thymoquinone (TQ), the major constituent of the black seed, on the expression levels of VEGFA and its receptor FLT1 in human estrogen receptor-positive breast adenocarcinoma (MCF-7) cells. The researchers provide evidence that TQ down-regulated VEGFA and up-regulated FLT1 transcriptional levels in human breast cancer cells compared to HEK293 cells. To the best of the researchers' knowledge, this is the first study determining the effect of TQ in VEGFA and its receptor FLT1 in MCF-cells and more comprehensive investigations are highly recommended. |
| Anahtar Kelimeler |
| Angiogenesis | Breast Tumor | MCF-7 Cells | Thymoquinone | Transcription |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 4 |
| Google Scholar | 4 |