Evaluation of CDH1 Promoter Methylation and HPV Infection Status in the Development of Parotid Pleomorphic Adenoma
Yazarlar (5)
Filiz Özen
Doç. Dr. Zeynep YEĞİN Sinop Üniversitesi, Türkiye
Prof. Dr. Gül Acar İstanbul Medeniyet Üniversitesi, Türkiye
Doç. Dr. Cumhur AVŞAR Sinop Üniversitesi, Türkiye
Tülay Zenginkinet
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | INTERNATIONAL JOURNAL OF HUMAN GENETICS (Q4) | ||
| Dergi ISSN | 0972-3757 Dergi Bilgileri (2020) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2020 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-01-2020 |
| Cilt / Sayı / Sayfa | 20 / 1 / 11–18 | DOI | 10.31901/24566330.2020/20.01.745 |
| Makale Linki | http://dx.doi.org/10.31901/24566330.2020/20.01.745 | ||
| UAK Araştırma Alanları |
Tıbbi Biyoloji
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| Özet |
| Both benign and malignant salivary gland tumors are clinically heterogeneous and they display different histology. Researchers aimed to elucidate the potential roles of both CDH1 methylation and high-risk oncogenic human papilloma virus (HPV) types HPV16 and HPV18 in parotid pleomorphic adenoma. Genomic DNA samples extracted from formalin-fixed paraffin-embedded (FFPE) samples of parotid pleomorphic adenoma and control tissues were subjected to methylation specific PCR (MSP) for hypermethylation analyses. HPV infection presence was evaluated using both GP5+/GP6+ consensus primers and type-specific primers for HPV16 and HPV18. Both CDH1 promoter hypermethylation and HPV16 infection partially seemed to be responsible in the occurrence of the tumors. According to the best of the researchers’ knowledge, this is the first study investigating the possible roles of both CDH1 methylation and HPV involvement in parotid pleomorphic adenoma. Multicentered studies with larger sample cohorts could be highly beneficial to strengthen this study’s results and thus draw a more precise conclusion |
| Anahtar Kelimeler |
| CDH1 | HPV16 | HPV18 | Human Papilloma Virus | Hypermethylation | Parotid Gland Tumor |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Google Scholar | 4 |