Protective effects of curcumin and Ganoderma lucidum on hippocampal damage caused by the organophosphate insecticide chlorpyrifos in the developing rat brain: Stereological ...
Yazarlar (1)
Doç. Dr. Dilek SAĞIR Sinop Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Acta Histochemica (Q4) | ||
| Dergi Tarandığı Indeksler | |||
| Makale Dili | Türkçe | Basım Tarihi | 10-2020 |
| Cilt / Sayı / Sayfa | 122 / 7 / 151621–0 | DOI | – |
| Makale Linki | https://www.sciencedirect.com/science/article/pii/S0065128120301203 | ||
| UAK Araştırma Alanları |
Eğitim Bilimleri
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| Özet |
| The aim of this study is to draw attention to the possible effects of chlorpyrifos exposure on the developing rat hippocampus in the prenatal period and to determine whether these effects can be reduced with various antioxidant substances.Pregnant rats were divided into 7 groups.; Chlorpyrifos (CPF), Curcumin (CUR), Ganoderma lucidum (GNL), Chlorpyrifos + Curcumin (CPF + CUR), Chlorpyrifos + Ganoderma lucidum, (CPF + GNL), SHAM and Control (C). After the experiments, brain tissues were evaluated by stereological and immunohistochemical methods.As a result of the stereological analyzes, it was determined that the number of pyramidal neurons in the hippocampus of the CPF group decreased significantly from all other groups. In contrast, the number of neurons in the CPF + CUR and CPF + GNL groups was significantly higher than the CPF group. In addition, immunohistochemical ... |
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