Protective effects of curcumin and resveratrol on neurodegeneration and cognitive dysfunction in a streptozotocin-induced alzheimer rat model
Yazarlar (1)
Doç. Dr. Dilek SAĞIR Sinop Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Scientific Reports (Q1) | ||
| Dergi ISSN | 2045-2322 Dergi Bilgileri (2026) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 04-2026 |
| Kabul Tarihi | 07-04-2026 | Yayınlanma Tarihi | 18-04-2026 |
| Cilt / Sayı / Sayfa | 16 / 1 / – | DOI | 10.1038/s41598-026-48216-9 |
| Makale Linki | https://doi.org/10.1038/s41598-026-48216-9 | ||
| UAK Araştırma Alanları |
Hücre Biyolojisi
Moleküler Biyoloji
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| Özet |
| Background Alzheimer's disease (AD) is a degenerative neurological disorder characterized by progressive impairment of memory, cognition, and behavior. Since current treatment approaches have been unable to significantly slow the progression of the disease, there is an increasing need for new neuroprotective strategies. This study aims to investigate the protective effects of curcumin and resveratrol on neurotoxicity and the resulting cognitive impairments. Methods A total of 60 male Wistar albino rats were included in the study. On day 1, an experimental Alzheimer's model was induced by a single intracerebroventricular injection of streptozotocin (STZ) at a dose of 3 mg/kg. Following model induction, the animals were randomly assigned into six groups: Alzheimer's disease (ALZ) group, ALZ+ curcumin (ALZ+ CUR) group, ALZ+ resveratrol (ALZ+ RES) group, ALZ+ curcumin+ resveratrol (ALZ+ CUR+ RES) group, SHAM group, and control group. Morris water maze test, open field test and passive avoidance test were used for behavioral tests; GFAP and caspase-3 tests for immunohistochemical analysis; TAS/TOS values for biochemical analysis and Cavalieri method for stereological examination. Results Behavioral tests demonstrated that curcumin and resveratrol significantly improved neurobehavioral outcomes. Histological analyses revealed that curcumin and resveratrol reduced the density of cells stained with Caspase 3 (+) and glial fibrillary acidic protein (GFAP)(+), thereby alleviating neuronal cell death and astrocyte activation. Stereological analyses demonstrated that curcumin and resveratrol improved the STZ-induced ... |
| Anahtar Kelimeler |
| Alzheimer’s disease | Cognitive impairment | Curcumin | Neuroinflammation | Neuroprotection | Oxidative stress | Resveratrol | Streptozotocin-induced model |
BM Sürdürülebilir Kalkınma Amaçları
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| Google Scholar | 1 |