Copper(II) and zinc(II) complexes of N2O2-thiosemicarbazones as inhibitors of Mycobacterium tuberculosis and bacterial quorum sensing
Yazarlar (9)
Arş. Gör. Büşra Kaya Griffith University, Avustralya
Siva Krishna Vagolu
Universitetet I Oslo, Norveç
Universitetet I Oslo, Norveç
Ayşe Karagüzel Hacettepe Üniversitesi, Türkiye
Sanja Skaro Bogojevic
University Of Belgrade, Sırbistan
University Of Belgrade, Sırbistan
Prof. Dr. Onur ŞAHİN Sinop Üniversitesi, Türkiye
Tone Tønjum Universitetet I Oslo, Norveç
Jasmina Nikodinovic-Runic
University Of Belgrade, Sırbistan
University Of Belgrade, Sırbistan
Miyase Gözde Gündüz Hacettepe Üniversitesi, Türkiye
Bahri Ülküseven
Istanbul University-Cerrahpasa, Türkiye
Istanbul University-Cerrahpasa, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Molecular Structure (Q2) | ||
| Dergi ISSN | 0022-2860 Dergi Bilgileri (2026) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2026 |
| Cilt / Sayı / Sayfa | 1362 / 1 / 145676– | DOI | 10.1016/j.molstruc.2026.145676 |
| UAK Araştırma Alanları |
Yoğun Madde Fiziği
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| Özet |
| The rise of resistance to existing antimicrobial drugs has become a significant global health concern, underscoring the urgent need for new and effective antimicrobial agents. In this context, we prepared six copper(II) (Cu1-Cu6) and six zinc(II) (Zn1-Zn6) complexes bearing N2O2-thiosemicarbazones and confirmed their structures using spectral techniques, including X-ray diffraction analysis. The antimicrobial potential of the target compounds was initially tested against drug-sensitive and isoniazid-resistant Mycobacterium tuberculosis strains. Cu(II)-based complexes were identified as more effective antitubercular agents with negligible cytotoxicity compared to Zn(II)-including counterparts. Furthermore, Cu1-Cu6 and Zn1-Zn6 were tested for their antibacterial and antifungal properties. Although the compounds failed to inhibit the growth of bacterial and fungal strains at low concentrations, Zn1 and Zn2 were … |
| Anahtar Kelimeler |
| "Antibacterial" | "Antitubercular" | "Antimicrobial" | "Tuberculosis" | "Thiosemicarbazone" | "Cytotoxicity" |
Science Direct
Copper(II) and zinc(II) complexes of N2O2-thiosemicarbazones as inhibitors of Mycobacterium tuberculosis and bacterial quorum sensing
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 2 |
| Scopus | 2 |
| Google Scholar | 1 |