Cytotoxic and oxidative stress-related effects of N2O2-type Ni(II)-thiosemicarbazone complexes: Experimental and computational studies
Yazarlar (6)
Doç. Dr. Adem GÜNER Sinop Üniversitesi, Türkiye
Qumars Poladian Kabul University, Afganistan
Tuncay Karakurt Kırşehir Ahi Evran Üniversitesi, Türkiye
Berat Ilhan-Ceylan
Istanbul Üniversitesi, Türkiye
Istanbul Üniversitesi, Türkiye
Prof. Dr. Onur ŞAHİN Sinop Üniversitesi, Türkiye
Prof. Dr. Yasemin Kurt Istanbul Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Chemico Biological Interactions (Q1) | ||
| Dergi ISSN | 0009-2797 Dergi Bilgileri (2026) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2026 |
| Cilt / Sayı / Sayfa | 430 / 1 / 111995– | DOI | 10.1016/j.cbi.2026.111995 |
| UAK Araştırma Alanları |
Yoğun Madde Fiziği
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| Özet |
| New thiosemicarbazone-based Ni(II) complexes, [Ni(L1–3)] (1–3), were synthesized, structurally characterized, and evaluated for their cytotoxic potential in a panel of human cervical (HeLa), lung (A549), breast (MDA-MB-231), and pancreatic (PANC-1) cancer cells, along with a non-cancerous human embryonic kidney (HEK-293) cell line. The complexes exhibited selective cytotoxic effects, with HeLa cells showing the highest sensitivity. Among them, complex 2 demonstrated the most pronounced antiproliferative activity and selectivity compared to complexes 1 and 3. Cellular studies in HeLa cells revealed increased oxidative stress markers, mitochondrial dysfunction, and apoptosis-related alterations accompanying the observed cytotoxicity. Chemical antioxidant assays indicated higher radical-scavenging activity for the free ligand, whereas complex 2 displayed the highest TEAC value among the metal … |
| Anahtar Kelimeler |
| "Thiosemicarbazone" | "Propiophenone" | "Nickel" | "Citotoxicity" | "Antioxidant" | "Molecular docking" |
Science Direct
Cytotoxic and oxidative stress-related effects of N2O2-type Ni(II)-thiosemicarbazone complexes: Experimental and computational studies
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Scopus | 1 |
| Google Scholar | 1 |