Bacopa Monnieri Protects the Directly Affected Organ as Well as Distant Organs Against I/R Injury by Modulating Anti-Inflammatory and Anti-Nitrosative Pathways in A Rat Model for Infra-Renal Aortic Occlusion
Yazarlar (6)
Hilal Ozlu Gazi University, Faculty of Medicine, Türkiye
Prof. Dr. Ayşe GÜNDOĞDU Sinop Üniversitesi, Türkiye
Dr. Öğr. Üyesi Zubeyir Elmazoglu Gazi University, Faculty of Medicine, Türkiye
Prof. Dr. Gulnur Take Kaplanoglu Gazi University, Faculty of Medicine, Türkiye
Levent Oktar Gazi University, Faculty of Medicine, Türkiye
Prof. Dr. Cimen Karasu Gazi University, Faculty of Medicine, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Investigative Surgery (Q2) | ||
| Dergi ISSN | 0894-1939 Dergi Bilgileri (2021) | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2021 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 31-01-2020 |
| Cilt / Sayı / Sayfa | 34 / 9 / 935–946 | DOI | 10.1080/08941939.2020.1716118 |
| Makale Linki | https://www.tandfonline.com/doi/full/10.1080/08941939.2020.1716118 | ||
| UAK Araştırma Alanları |
Ziraat, Orman ve Su Ürünleri
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| Özet |
| Objective: To investigate the protective effect and underlying mechanisms of B. monnieri, a medicinal plant, on kidney and skeletal muscle injury induced by infra-renal abdominal aorta clamping for 2-hours (ischemia) and following removal of the clamp (reperfusion, 2-hours). Methods: Rats were divided into four groups (n = 6): (I) animals given only saline (sham-control); (II) animals given B. monnieri extract for 10-days (300 mg/kg/day) (Bacopa-treated sham); (III) animals subjected to ischemia/reperfusion (I/R); (IV) animals given B. monnieri extract and then subjected to I/R. Kidneys and lower extremity muscles were examined for GPx, CAT, iNOS, 3-NT, IL-1β and TNF-α. Apoptosis and injury were evaluated by TUNEL and H&E staining, respectively. Results: I/R resulted in TUNEL positive cells, periarterial edema and glomerular capillary dilatation, decreased GPx activity, unchanged CAT, iNOS, 3-NT, IL-1β and TNF-α in kidney. B. monnieri minimized renal remote reperfusion injury, and Group IV showed a lower degree of renal histopathology score when compared to the others. B. monnieri mitigated muscle I/R injury, decreased muscle hypertrophy, myofibril abnormalities and apoptosis. Muscle 3-NT and cytokine levels were increased by I/R, and B. monnieri inhibited iNOS and 3-NT both in sham-control and I/R groups. Muscle GPx unaffected by I/R or B. monnieri, but CAT was inhibited only in B. monnieri-treated I/R group. Muscle iNOS, 3-NT, IL-1β, TNF-α levels and CAT activity of B. monnieri-treated I/R rats were lower than those in sham-control or Bacopa-treated sham. Conclusions: B. monnieri can protect the directly affected organ as well as distant organs against I/R injury by modulating anti-inflammatory and anti-nitrosative pathways. |
| Anahtar Kelimeler |
| apoptosis | Bacopa monnieri | inflammation | infra-renal aortic occlusion | ischemia–reperfusion | nitrosative stress |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 5 |