Vitellogenin as a Basic Biomarker: Endocrine Disruptor Effects of Sodium Pyrithione on Zebrafish (Danio Rerio)
Yazarlar (5)
Rabia Şemsi
Gazi Üniversitesi, Türkiye
Gazi Üniversitesi, Türkiye
Prof. Dr. Aysel Çağlan Günal Gazi Üniversitesi, Türkiye
Dr. Öğr. Üyesi Rabia TURAL Sinop Üniversitesi, Türkiye
Aylin Sepici Dinçel Gazi University, Faculty Of Medicine, Türkiye
Prof. Dr. Figen Erkoç Başkent Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Applied Toxicology (Q2) | ||
| Dergi ISSN | 0260-437X Dergi Bilgileri (2026) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Ingilizce | Basım Tarihi | 01-2026 |
| Cilt / Sayı / Sayfa | 46 / 8 / 2830–2836 | DOI | 10.1002/jat.70075 |
| Makale Linki | https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/jat.70075 | ||
| UAK Araştırma Alanları |
Tıbbi Biyokimya
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| Özet |
| In recent years, one of the most striking consequences of overpopulation and consumption activities worldwide has been the rapid increase in environmental pollutants. Sodium pyrithione (NaPT) is an organosulfur compound commonly used for its antimicrobial and antifungal properties in industrial and personal care products. The primary objective of this study was to determine the impact of NaPT exposure on whole‐body vitellogenin (Vtg) levels in adult male zebrafish, a highly relevant model for toxicological studies. As Vtg functions as a key estrogen‐responsive biomarker, its induction serves as a critical indicator for assessing endocrine disruption, thereby justifying its selection as the primary endpoint. The adaptation period completed, stocked zebrafish were transferred to experimental aquariums and exposed to 1 and 5 μg/L concentrations of NaPT for 24, 72, 96 h, and 7 days. Commercial ELISA kits … |
| Anahtar Kelimeler |
| environmental pollutant | pyrthion | sodium pyrithione | vitellogenin | zebrafishendocrine distruptor |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Scopus | 1 |
| Google Scholar | 1 |