Novel Schiff base-Pt(ii) complexes: inhibition of Aβ aggregation via histidine interaction
Yazarlar (5)
Prof. Dr. Sevil Irişli Ege Üniversitesi, Türkiye
Doç. Dr. Umut Doğan Ege Üniversitesi, Türkiye
Salih Günnaz Ege Üniversitesi, Türkiye
Prof. Dr. Fatma Yurt Ege Üniversitesi, Türkiye
Prof. Dr. Onur ŞAHİN Sinop Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | New Journal of Chemistry (Q3) | ||
| Dergi ISSN | 1144-0546 Dergi Bilgileri (2026) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2026 |
| Cilt / Sayı / Sayfa | 50 / 2 / 1125–1138 | DOI | 10.1039/d5nj04180e |
| UAK Araştırma Alanları |
Yoğun Madde Fiziği
|
||
| Özet |
| In this study, three Schiff base ligands (L1–L3) and their novel platinum(II) complexes (I–III) were synthesized and characterized using FT-IR, NMR, and elemental analysis. The crystal structure of complex I was determined by X-ray crystallography, while the lipophilicity of the complexes was evaluated by UV-Vis spectroscopy. The ability of the compounds to inhibit Aβ aggregation was assessed using the SH-SY5Y human neuroblastoma cell line. Due to its high cytotoxicity, comparable to that of cisplatin, complex II was excluded from further biological investigations. The kinetics of Aβ aggregation inhibition were examined fluorometrically using Thioflavin-T, and the binding interactions of the complexes with the Aβ1–42 sequence were elucidated through studies of their interactions with L-histidine using 1H-NMR and LC/QTOF/MS analyses. The results demonstrate that complexes I and III significantly suppress Aβ … |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Google Scholar | 1 |