Fasted-State Aerobic Exercise Enhances Cognition and Hippocampal BDNF Signaling in an Alzheimer’s Disease Rat Model
Yazarlar (6)
Doç. Dr. Fatih Kırkbir Karadeniz Technical University, Türkiye
Doç. Dr. Taner Atasoy Istanbul Gelişim Üniversitesi, Türkiye
Davar Khodadadai
Islamic Azad University, Central Tehran Branch
Islamic Azad University, Central Tehran Branch
Heidar Sajedi
International Science And Technology University, Polonya
International Science And Technology University, Polonya
Prof. Dr. Özlem KESKİN Sinop Üniversitesi, Türkiye
Mohammad Babaie
University Of Mohaghegh Ardabili
University Of Mohaghegh Ardabili
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Neurochemical Research (Q2) | ||
| Dergi ISSN | 0364-3190 Dergi Bilgileri (2025) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2025 |
| Kabul Tarihi | 11-12-2025 | Yayınlanma Tarihi | 20-12-2025 |
| Cilt / Sayı / Sayfa | 51 / 1 / – | DOI | 10.1007/s11064-025-04637-y |
| Makale Linki | https://doi.org/10.1007/s11064-025-04637-y | ||
| UAK Araştırma Alanları |
Hareket ve Beceri Öğretimi
Fiziksel Uygunluk
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| Özet |
| Alzheimer’s disease (AD) is a multifactorial disorder that demands a comprehensive management strategy. Both aerobic exercise training and intermittent fasting (IF) have been shown to ameliorate AD symptoms, yet the impact of exercise in the fasted state remains understudied. This study compared the effects of four weeks of moderate‑intensity treadmill running in either a fasted or a normal fed state on cognitive function and hippocampal BDNF signaling in an amyloid-β (Aβ) 1–42-injected rat model of AD. Twenty‑month‑old male Wistar rats were allocated into five groups (n= 12 each): AD, AD plus IF (ADIF), AD plus exercise training (ADET), AD plus IF plus exercise training (ADIFET), and control. AD was induced by bilateral intra‑hippocampal Aβ 1–42 injection. Exercise interventions (fasted or fed) were conducted 5 days/week for 4 weeks. Aβ injection significantly impaired learning and memory and reduced … |
| Anahtar Kelimeler |
| Aerobic exercise | Alzheimer's disease | BDNF | Cognitive function | Intermittent fasting | Β-hydroxybutyrate |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Scopus | 1 |
| Google Scholar | 2 |