Polyphenols containing new azo–aroylhydrazone hybrids: theoretical insights and evaluation of antioxidant potential via CUPRAC and DPPH assays
Yazarlar (1)
Doç. Dr. Tolga Acar YEŞİL Sinop Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Bioorganic Chemistry (Q1) | ||
| Dergi ISSN | 0045-2068 Dergi Bilgileri (2026) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 01-2026 |
| Cilt / Sayı / Sayfa | 168 / 1 / 109377–0 | DOI | 10.1016/j.bioorg.2025.109377 |
| Makale Linki | https://doi.org/10.1016/j.bioorg.2025.109377 | ||
| UAK Araştırma Alanları |
Organik Kimya
Spektroskopi
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| Özet |
| The growing interest in multifunctional antioxidants has drawn attention to hybrid scaffolds that unify distinct redox-active pharmacophores. Azo groups, aroylhydrazones, and gallic acid derivatives are individually recognized for their notable antioxidant potential, yet molecular hybrids integrating all three remain scarce. To address this gap, a new series of compounds (5a–j) combining azo, aroylhydrazone, and polyhydroxyphenyl moieties was designed and synthesized to enhance antioxidant activity through structural synergy. The synthesized molecules were thoroughly characterized by FTIR, 1H, 13C NMR, 2D NOESY/COSY, UV–Vis, and mass spectrometry. Their electronic and structural properties were further evaluated using DFT calculations at the B3LYP/6–311++G(d,p) level. In silico ADMEt predictions and molecular docking studies revealed favorable pharmacokinetic profiles and strong binding affinities … |
| Anahtar Kelimeler |
| Aroylhydrazone | CUPRAC | DPPH | Molecular docking | Quantum chemical calculations |
Science Direct
Polyphenols containing new azo–aroylhydrazone hybrids: theoretical insights and evaluation of antioxidant potential via CUPRAC and DPPH assays
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 7 |
| Scopus | 6 |
| Google Scholar | 9 |