α-Glucosidase inhibition properties of novel azaphthalocyanines containing vanillin
Yazarlar (1)
Prof. Dr. Onur ŞAHİN Sinop Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SCOPUS dergilerinde yayınlanan tam makale)
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| Dergi Adı | Indian Journal of Chemistry Ijc | ||
| Dergi ISSN | 2583-1321 Dergi Bilgileri (2023) | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2023 |
| Cilt / Sayı / Sayfa | 62 / 7 / 728–734 | DOI | 10.56042/IJC.V62I7.3730 |
| Makale Linki | https://or.niscpr.res.in/index.php/IJC/article/view/3730 | ||
| UAK Araştırma Alanları |
Fen Bilimleri ve Matematik
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| Özet |
| Vanillin substituted novel zinc (II) azaphthalocyanines (ZnAzaPcs) have been synthesized and investigated for their α-glucosidase inhibition properties. The new compounds (1, 2, 1a and 2a) have been characterised using a combination of FT-IR, ¹H and ¹³C NMR, UV-Vis, MS and elemental analysis. The crystal structures of starting pyrazine compounds 1 and 2 have also been determined by the single crystal diffraction technique. All newly synthesized compounds have been evaluated for their in vitro inhibitory activity against α-glucosidase and all of them have more inhibitory effect when compared to acarbose as reference compound. Especially, compound 2 shows the most significant α-glucosidase inhibition. IC50 values of compound 2 and acarbose, which is known as α-glucosidase inhibitor used as anti-diabetic drug, have been found to be 6.01±0.16 and 9.52±0.23 µg/mL, respectively. |
| Anahtar Kelimeler |
| Azaphthalocyanine | Vanillin | α-Glucosidase inhibition |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 2 |
| Scopus | 2 |
| Google Scholar | 2 |