Structural characterization of new zinc (ii) complexes with N 2 O 2 chelating thiosemicarbazidato ligands; investigation of the relationship between their DNA interaction and ...
Yazarlar (5)
Arş. Gör. Büşra Kaya İstanbul Üniversitesi, Türkiye
Arş. Gör. Zehra Kübra Yılmaz İstanbul Üniversitesi, Türkiye
Prof. Dr. Onur ŞAHİN Sinop Üniversitesi, Türkiye
Prof. Dr. Belma Aslim İstanbul Üniversitesi, Türkiye
Bahri Ülküseven
İstanbul Üniversitesi, Türkiye
İstanbul Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | New Journal of Chemistry (Q2) | ||
| Dergi Tarandığı Indeksler | |||
| Makale Dili | İngilizce | Basım Tarihi | 01-2020 |
| Cilt / Sayı / Sayfa | 44 / 22 / 9313–9320 | DOI | – |
| Makale Linki | https://pubs.rsc.org/en/content/articlehtml/2020/nj/d0nj02149k | ||
| UAK Araştırma Alanları |
Fen Bilimleri ve Matematik
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| Özet |
| Two new zinc(II) complexes were synthesized by condensation of 4,4,4-trifluoro-1-(2-thienyl)-1,3-butanedione-S-methyl-thiosemicarbazone with salicylaldehyde or 4-methoxy-salicylaldehyde. Structures of the N2O2-chelate complexes, Zn1 and Zn2, were explicated by IR, 1H NMR, ESI-MS and X-ray crystallography. Electronic spectral analysis was performed to assign the nature of the interaction between the complexes and calf thymus DNA (CT-DNA). DNA cleavage activities of the complexes were investigated by gel electrophoresis (pBR322 DNA). The results indicated that the complexes bind to CT-DNA via an intercalation mode and the binding of Zn2 is stronger than that of Zn1. Relatively high concentrations of the zinc complexes were found to encourage the cleavage of DNA from supercoiled form (Form I) to nicked circular form (Form II). The antiproliferative activity of the complexes was determined against … |
| Anahtar Kelimeler |
