A square planar cobalt(II)-thiosemicarbazone complex. Synthesis, characterization, antiviral and anti-inflammatory potential
Yazarlar (4)
Prof. Dr. Belkıs Atasever Arslan Üsküdar Üniversitesi, Türkiye
Arş. Gör. Büşra Kaya Istanbul University-Cerrahpasa, Türkiye
Prof. Dr. Onur ŞAHİN Sinop Üniversitesi, Türkiye
Bahri Ülküseven
Istanbul University-Cerrahpasa, Türkiye
Istanbul University-Cerrahpasa, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Molecular Structure (Q2) | ||
| Dergi ISSN | 0022-2860 Dergi Bilgileri (2025) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2025 |
| Cilt / Sayı / Sayfa | 1321 / 1 / 140109–0 | DOI | 10.1016/j.molstruc.2024.140109 |
| Makale Linki | https://doi.org/10.1016/j.molstruc.2024.140109 | ||
| UAK Araştırma Alanları |
Yoğun Madde Fiziği
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| Özet |
| Considering the possible antiviral effect of cobalt compounds and known pharmacological potential of thiosemicarbazones, a new combination containing cobalt(II) ions and tetradentate thiosemicarbazone was synthesized and structurally analyzed. In the complex structure (Co1), the cobalt ion is in 2+ oxidation state and is coordinated with ONNO donor set on the thiosemicarbazone backbone. The complex molecule crystallizes in the space group P21/m and the environment of the cobalt center tends to square planar geometry. The inhibitory performance of SARS-CoV-2 and the anti-inflammatory impact of the complex molecule were investigated. It was found that Co1 has high inhibitory effects on the SARS-CoV-2 virus's 3CL main protease enzyme, ACE2:SARS-CoV2 Spike RBD interaction, and IL8. Also, it showed significant anti-inflammatory effects on the release of IL6, IL8, IL10, and TGFβ1 cytokines and … |
| Anahtar Kelimeler |
| Cobalt | COVID19 | IL8 | Inflammation | SARS-CoV-2 | Thiosemicarbazone |
Science Direct
A square planar cobalt(II)-thiosemicarbazone complex. Synthesis, characterization, antiviral and anti-inflammatory potential
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 12 |
| Scopus | 10 |
| Google Scholar | 15 |