Synthesis, Characterization, Crystal Structure, and BSA‐Binding Properties with the Presence of Ca2+, Mg2+, and Zn2+ Ions by N(7)‐Substituted Theophyllines
Yazarlar (4)
Prof. Dr. Serpil Demir Düşünceli Inönü Üniversitesi, Türkiye
Prof. Dr. Murat Kaloğlu Inönü Üniversitesi, Türkiye
Prof. Dr. Onur ŞAHİN Sinop Üniversitesi, Türkiye
Prof. Dr. Elvan Üstün Ordu Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Chemistryselect (Q3) | ||
| Dergi ISSN | 2365-6549 Dergi Bilgileri (2025) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2025 |
| Kabul Tarihi | 08-06-2025 | Yayınlanma Tarihi | 01-06-2025 |
| Cilt / Sayı / Sayfa | 10 / 24 / – | DOI | 10.1002/slct.202501358 |
| Makale Linki | https://doi.org/10.1002/slct.202501358 | ||
| UAK Araştırma Alanları |
Yoğun Madde Fiziği
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| Özet |
| Theophylline (1,3‐dimethylxanthine) contains a fused imidazole‐pyrimidine ring system with conjugated double bonds. It is a naturally occurring alkaloid that belonging to the xanthine family. Various substituted theophylline derivatives widely known as biologically active scaffolds. In this work, the N(7)‐substituted theophylline compounds were synthesized and characterized by 13C‐NMR, 1H NMR, elemental analysis, and FT‐IR spectroscopy. The crystal structure of 1,3‐dimethyl‐7‐[(3‐methylphenyl)methyl]‐2,3,6,7‐tetrahydro‐1H‐purine‐2,6‐dione, 1b, was determined by single crystal X‐ray diffraction analysis. The interactions of substituted theophylline type molecules with BSA were analyzed by the Stern–Volmer method and Stern–Volmer constants, rate constants, binding numbers, and binding constants of each molecule were determined. In addition, the interaction of BSA with the presence of Ca2+, Mg2 … |
| Anahtar Kelimeler |
| BSA binding | Fluorescent spectroscopy | Molecular docking | N(7)-substituted theophylline | X-ray diffraction |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Scopus | 1 |
| Google Scholar | 3 |
| Google Scholar | 1 |