Vanadyl(III)-(E)-N′-(3,5-di-tert-butyl-2-hydroxybenzylidene)-nicotinohydrazide complex: Synthesis, characterization and in vitro and in silico cholinesterase and α-glucosidase inhibition studies
Yazarlar (11)
Perizad Amrulla Fatullayeva
Institute Of Catalysis And Inorganic Chemistry Named After Academician M.Nagiyev Ministry Of Science, Azerbaycan
Institute Of Catalysis And Inorganic Chemistry Named After Academician M.Nagiyev Ministry Of Science, Azerbaycan
Ajdar Akper Medjidov
Institute Of Catalysis And Inorganic Chemistry Named After Academician M.Nagiyev Ministry Of Science, Azerbaycan
Institute Of Catalysis And Inorganic Chemistry Named After Academician M.Nagiyev Ministry Of Science, Azerbaycan
Doç. Dr. Halil Şenol Bezmiâlem Vakıf Üniversitesi, Türkiye
Dilgam Babir Tagiyev
Institute Of Catalysis And Inorganic Chemistry Named After Academician M.Nagiyev Ministry Of Science, Azerbaycan
Institute Of Catalysis And Inorganic Chemistry Named After Academician M.Nagiyev Ministry Of Science, Azerbaycan
Rayyat Huseyn Ismayilov
Institute Of Catalysis And Inorganic Chemistry Named After Academician M.Nagiyev Ministry Of Science, Azerbaycan
Institute Of Catalysis And Inorganic Chemistry Named After Academician M.Nagiyev Ministry Of Science, Azerbaycan
Prof. Dr. Onur ŞAHİN Sinop Üniversitesi, Türkiye
Victor Nikolaevic Khrustalev
Rudn University, Rusya Federasyonu
Rudn University, Rusya Federasyonu
Gulu Ganimat Abbasova
Institute Of Catalysis And Inorganic Chemistry Named After Academician M.Nagiyev Ministry Of Science, Azerbaycan
Institute Of Catalysis And Inorganic Chemistry Named After Academician M.Nagiyev Ministry Of Science, Azerbaycan
Arş. Gör. Furkan Çakır Bezmiâlem Vakıf Üniversitesi, Türkiye
Nastaran Sedeghian
Bartin Üniversitesi, Türkiye
Bartin Üniversitesi, Türkiye
Doç. Dr. Parham Taslımı Bartin Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Polyhedron (Q1) | ||
| Dergi ISSN | 0277-5387 Dergi Bilgileri (2025) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2025 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-12-2025 |
| Cilt / Sayı / Sayfa | 282 / 1 / 117783–0 | DOI | 10.1016/j.poly.2025.117783 |
| Makale Linki | https://doi.org/10.1016/j.poly.2025.117783 | ||
| UAK Araştırma Alanları |
Yoğun Madde Fiziği
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| Özet |
| A new ligand N-nicotinoyl-N′-(3,5-ditertbuthyl-2-hydroxy)benzylidene hidrazine (H2L) was synthesized and a complex [VO(L)CH3O·CH3OH] with this ligand was obtained and their structures investigated by X-ray crystallography. It was found that the methanol molecule in the complex is easily exchanged for a pyridine molecule. The effects of H2L and [VO(L)CH3O CH3OH] complexes against AChE, BChE and α-glucosidase enzymes were investigated using Ellman and Tao methods and the results were calculated as IC50 and Ki. Both compounds demonstrated effective inhibition of all three enzymes, with varying degrees of potency. For AChE, H2L exhibited the lowest IC50 value (8.45 μM, r2 = 0.993) and a Ki of 5.53 ± 0.73 μM, outperforming both its vanadium complex (IC50 = 10.61 μM, Ki = 7.38 ± 1.14 μM) and the reference drug tacrine (IC50 = 13.75 μM, Ki = 11.90 ± 1.01 μM … |
| Anahtar Kelimeler |
| Metal complexes | Nicotinic acid hydrazide | Schiff base | Spectroscopic | VO-complexes |
Science Direct
Vanadyl(III)-(E)-N′-(3,5-di-tert-butyl-2-hydroxybenzylidene)-nicotinohydrazide complex: Synthesis, characterization and in vitro and in silico cholinesterase and α-glucosidase inhibition studies
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Scopus | 2 |
| Google Scholar | 1 |