Copper(II) monohelix complexes with pyrazine-modulated long-chain oligo-α-aminopyridine ligand: synthesis, crystal structures, and bioactivity studies
Yazarlar (12)
Sabina Zahid Ismayilova Institute Of Catalysis And Inorganic Chemistry Named After Academician M.Nagiyev Ministry Of Science, Azerbaycan
Rayyat Huseyn Ismayilov
Institute Of Catalysis And Inorganic Chemistry Named After Academician M.Nagiyev Ministry Of Science, Azerbaycan
Institute Of Catalysis And Inorganic Chemistry Named After Academician M.Nagiyev Ministry Of Science, Azerbaycan
Dilgam Babir Tagiyev
Institute Of Catalysis And Inorganic Chemistry Named After Academician M.Nagiyev Ministry Of Science, Azerbaycan
Institute Of Catalysis And Inorganic Chemistry Named After Academician M.Nagiyev Ministry Of Science, Azerbaycan
Doç. Dr. Halil Şenol Bezmiâlem Vakıf Üniversitesi, Türkiye
Ajdar Akber Medjidov
Institute Of Catalysis And Inorganic Chemistry Named After Academician M.Nagiyev Ministry Of Science, Azerbaycan
Institute Of Catalysis And Inorganic Chemistry Named After Academician M.Nagiyev Ministry Of Science, Azerbaycan
Mansura Teyfur Huseynova
Academician A.M. Guliyev Institute Of Chemistry Of Additives Ministry Of Science And Education Repub, Azerbaycan
Academician A.M. Guliyev Institute Of Chemistry Of Additives Ministry Of Science And Education Repub, Azerbaycan
Prof. Dr. Bahattin Yalçın Marmara Üniversitesi, Türkiye
Doç. Dr. Parham Taslımı Bartin Üniversitesi, Türkiye
Namig Shahid Rasulov
Azerbaijan Medical University, Azerbaycan
Azerbaijan Medical University, Azerbaycan
Dr. Öğr. Üyesi Nastaran Sadeghian Bartin Üniversitesi, Türkiye
Prof. Dr. Onur ŞAHİN Sinop Üniversitesi, Türkiye
Shie-Ming Peng
National Taiwan University, Tayvan
National Taiwan University, Tayvan
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Molecular Structure (Q2) | ||
| Dergi ISSN | 0022-2860 Dergi Bilgileri (2025) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2025 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-12-2025 |
| Cilt / Sayı / Sayfa | 1347 / 1 / 143295–0 | DOI | 10.1016/j.molstruc.2025.143295 |
| Makale Linki | https://doi.org/10.1016/j.molstruc.2025.143295 | ||
| UAK Araştırma Alanları |
Yoğun Madde Fiziği
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| Özet |
| Using the pyrazine-modulated pentapyridyltetraamine ligand N2,N2′-(pyridine-2,6-diyl)bis(N6-(pyrazin-2-yl)pyridine-2,6-diamine) H4N9-2pz, three new mononuclear complexes [Cu(H4N9-2pz)](NO3)2∙(CH3CN) 1, [Cu(H4N9-2pz)]Cl2∙2(H2O) 2 and [Cu(H3N9-2pz)] (CH3COO)∙2.5(H2O) 3 have been synthesized, structurally characterized, and their bioactivity properties studied. In vitro analysis of complexes 1-3 revealed that they inhibited AChE and BChE more effectively than the widely available inhibitor tacrine (IC50: 123.58 ± 6.80 and 146.18 ± 7.91 µM). Additionally, their IC50 values for AChE and BChE ranged from 32.87 to 68.15 and 14.60 to 31.68 µM, respectively. The g|| and g┴ components of the g factor have similar values in the EPR spectrum of complexes 1-3 (g|| = 2.0179 and g┴ = 2.1246 for 1; g|| = 2.0044 and g┴ = 2.1425 for 2; g|| = 2.0118 and g┴ = 2.1356 for 3). The single crystal X … |
| Anahtar Kelimeler |
| Copper complex | Enzyme inhibition | Hydrogen bonds | Modulated oligo-α-aminopyridine ligand | Supramolecular networks |
Science Direct
Copper(II) monohelix complexes with pyrazine-modulated long-chain oligo-α-aminopyridine ligand: synthesis, crystal structures, and bioactivity studies
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 5 |
| Scopus | 3 |
| Google Scholar | 7 |