The Amyloid Beta Aggregation Inhibition Properties of New Pt (II) Complexes and Their Potential in Alzheimers Treatment
Yazarlar (3)
Salih Günnaz Ege Üniversitesi, Türkiye
Prof. Dr. Onur ŞAHİN Sinop Üniversitesi, Türkiye
Prof. Dr. Sevil İrişli Ege Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Applied Organometallic Chemistry (Q1) | ||
| Dergi ISSN | 0268-2605 Dergi Bilgileri (2025) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 04-2025 |
| Kabul Tarihi | 31-03-2025 | Yayınlanma Tarihi | 10-04-2025 |
| Cilt / Sayı / Sayfa | 39 / 5 / – | DOI | 10.1002/aoc.70159 |
| Makale Linki | https://doi.org/10.1002/aoc.70159 | ||
| UAK Araştırma Alanları |
Yoğun Madde Fiziği
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| Özet |
| In this study, N‐phenylortho‐phenylenediamine and N‐phenyl ethylenediamine were utilized as amines, and two novel ligands, benzimidazole (LI) and Schiff base (LII), were synthesized through condensation reactions with 3‐methoxy‐4‐benzyloxybenzaldehyde. Furthermore, using these same amines, LIII (benzimidazole) with 3‐phenoxybenzaldehyde and LIV (Schiff base) with 4‐benzyloxybenzaldehyde were synthesized in accordance with the literature. Then, Pt (II) complexes (Ia, Ib, II, III, and IV) were prepared with these ligands, and it was determined that Ia and Ib are geometric isomers. The ligands and complexes were characterized using 1H‐NMR, 13C‐NMR, FT‐IR, and elemental analysis methods. The cytotoxic effects of these complexes were evaluated on SH‐SY5Y neuronal cells. Low‐toxicity complexes Ia, II, and IV were then tested for their ability to inhibit amyloid beta (Aβ1–42) aggregation … |
| Anahtar Kelimeler |
| anti-Alzheimer activity | benzimidazole | platinum complexes | Schiff base |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 2 |
| Scopus | 2 |
| Google Scholar | 2 |